| Literature DB >> 17400012 |
Paula C Jimenez1, Diego V Wilke1, Renata Takeara2, Tito M C Lotufo3, Cláudia Pessoa1, Manoel Odorico de Moraes1, Norberto P Lopes4, Letícia V Costa-Lotufo5.
Abstract
This study consists of the bioassay-guided fractionation of the dichloromethane extract from Eudistoma vannamei and the pharmacological characterization of the active fractions. The dried hydromethanolic extract dissolved in aqueous methanol was partitioned with dichloromethane and chromatographed on a silica gel flash column. The anti-proliferative effect was monitored by the MTT assay. Four of the latest fractions, numbered 14 to 17, which held many chemical similarities amongst each other, were found to be the most active. The selected fractions were tested for viability, proliferation and death induction on cultures of HL-60 promyeloblastic leukemia cells. The results suggested that the observed cytotoxicity is related to apoptosis induction.Entities:
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Year: 2007 PMID： 17400012 DOI： 10.1016/j.cbpa.2007.02.018
Source DB: PubMed Journal: Comp Biochem Physiol A Mol Integr Physiol ISSN： 1095-6433 Impact factor: 2.320