Literature DB >> 17399988

Monitoring aminoglycoside-induced conformational changes in 16S rRNA through acrylamide quenching.

Pei-Wen Chao1, Christine S Chow.   

Abstract

Fluorescence of 2-aminopurine (2AP)-substituted A-site and acrylamide quenching were used to study the interactions of paromomycin and neamine with the decoding region of 16S rRNA. The results reveal that paromomycin binding to the A-site RNA leads to increased exposure of residue A1492. In contrast, neamine has little effect on the solvent accessibility of A1492. Electrospray ionization mass spectrometry was used to compare the affinity of paromomycin with the A-site and 2-AP-substituted A-site RNAs.

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Year:  2007        PMID： 17399988      PMCID： PMC2001229          DOI： 10.1016/j.bmc.2007.03.025

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


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