Literature DB >> 17399853

Early impairment of synaptic plasticity in patients with Down's syndrome.

Fortunato Battaglia1, Angelo Quartarone, Vincenzo Rizzo, Maria Felice Ghilardi, Alessandro Di Rocco, Gaetano Tortorella, Paolo Girlanda.   

Abstract

We investigated synaptic plasticity in persons with Down' syndrome (DS) and control subjects used paired associative stimulation (PAS) protocol, a paradigm capable of producing long-term potentiation (LTP)-like changes in the sensorimotor system. After PAS, patients showed less LTP-like plasticity compared to control subjects. Abnormal motor cortex synaptic plasticity may play a role in the development of motor signs in DS.

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Year:  2007        PMID： 17399853     DOI： 10.1016/j.neurobiolaging.2007.02.025

Source DB:  PubMed          Journal:  Neurobiol Aging        ISSN： 0197-4580            Impact factor:   4.673


  9 in total

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