| Literature DB >> 17399748 |
Jun Ma1, Moul Dey, Hui Yang, Alexander Poulev, Reneta Pouleva, Ruth Dorn, Peter E Lipsky, Edward J Kennelly, Ilya Raskin.
Abstract
The extract of Tripterygium wilfordii Hook F. (TwHF), which showed anti-inflammatory and immunosuppressive activities in human clinical trials for rheumatoid arthritis, was subjected to the activity-guided fractionation and spectroscopic characterization of bioactives. A tetrahydrofuran lignan, tripterygiol (1), and eight known compounds, all capable of suppressing pro-inflammatory gene expression were identified. Most of the pharmacological activity of the extract can be attributed to triptolide, its most abundant and active component, with some contribution from tripdiolide.Entities:
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Year: 2007 PMID： 17399748 DOI： 10.1016/j.phytochem.2007.02.021
Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072