| Literature DB >> 17398004 |
Lijun Xu1, Bingyin Wang, Kirandeep Kaur, Melanie F Kho, John P Cooke, Rona G Giffard.
Abstract
Both nitric oxide and asymmetric dimethylarginine (ADMA) play a critical role in the regulation of cerebral blood flow, though their neuroprotective and cytotoxic effects are still under investigation. In this study, we found that nitrate/nitrite (NOx) levels in plasma, ischemic brain tissue, and cerebrospinal fluid (CSF) increased significantly 24h after 2h transient middle cerebral artery occlusion (MCAO) in rats. ADMA levels were unchanged in plasma, but decreased significantly in CSF 24h following MCAO. The CSF ADMA/NOx ratio decreased markedly following ischemia. Rats protected by expression of the chaperonin GroEL or its folding deficient mutant D87K had lower plasma NOx levels at 24h reperfusion. ADMA, NO, and their ratio in CSF merit further study as biomarkers for ischemic brain injury.Entities:
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Year: 2007 PMID： 17398004 PMCID： PMC2430977 DOI： 10.1016/j.neulet.2007.03.021
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046