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Literature DB >> 17397173

Syntheses of amamistatin fragments and determination of their HDAC and antitumor activity.

Abstract

[reaction: see text] Amamistatins A and B are natural products found to have anti-proliferative effects against MCF-7, A549, and MKN45 human tumor cell lines (IC50 0.24-0.56 microM). It was proposed that their activity was due to histone deacetylase (HDAC) inhibition mediated by the N-formyl-N-hydroxy lysine moiety. Amamistatin B fragment analogs were synthesized and screened for biological activity. These compounds were modest HDAC inhibitors and showed antitumor activity against MCF-7 and PC-3 human tumor cells.

Entities: Chemical Disease Gene Species

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Year: 2007 PMID： 17397173 DOI： 10.1021/ol070382e

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

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Cited

7 in total

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2. N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)arylamide as a new scaffold that provides rapid access to antimicrotubule agents: synthesis and evaluation of antiproliferative activity against select cancer cell lines.

Authors: Jonathan A Stefely; Rahul Palchaudhuri; Patricia A Miller; Rebecca J Peterson; Garrett C Moraski; Paul J Hergenrother; Marvin J Miller
Journal: J Med Chem Date: 2010-04-22 Impact factor: 7.446

3. Syntheses and studies of amamistatin B analogs reveals that anticancer activity is relatively independent of stereochemistry, ester or amide linkage and select replacement of one of the metal chelating groups.

Authors: Chunrui Wu; Patricia A Miller; Marvin J Miller
Journal: Bioorg Med Chem Lett Date: 2011-01-22 Impact factor: 2.823

Syntheses of amamistatin fragments and determination of their HDAC and antitumor activity.

1. Epigenetic changes induced by curcumin and other natural compounds.

2. N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)arylamide as a new scaffold that provides rapid access to antimicrotubule agents: synthesis and evaluation of antiproliferative activity against select cancer cell lines.

3. Syntheses and studies of amamistatin B analogs reveals that anticancer activity is relatively independent of stereochemistry, ester or amide linkage and select replacement of one of the metal chelating groups.

4. Design, Synthesis, and Biological Evaluation of the First c-Met/HDAC Inhibitors Based on Pyridazinone Derivatives.

5. Histone deacetylase modulators provided by Mother Nature.

Review 6. Histone deacetylase inhibitors in clinical studies as templates for new anticancer agents.

Review 7. The diversity and utility of arylthiazoline and aryloxazoline siderophores: challenges of total synthesis.