Patrick Mbaya1, Faouzi Alam, Sindhu Ashim, David Bennett. 1. Department of Psychiatry, Laureate House, South Manchester University Hospital, Southmoor Road, Wythenshawe, Manchester, M23 9LT, UK. patrickmbaya@hotmail.co.uk
Abstract
OBJECTIVE: To assess cardiovascular safety profile of high dose Venlafaxine XL in patients with major depression. METHOD: Effects of high dose venlafaxine (mean 346.15 mg;) on the cardiovascular system in 37 patients with major depressive disorder were evaluated: BP, ECG (PR, QT, QRSD and QTc intervals) and heart rate. RESULTS: 12.5% of patients developed hypertension after starting treatment with venlafaxine. There was an association between heart rate and the dose of venlafaxine although not statistically significant. There was no association between dose of venlafaxine and PR, QT, QRSD and QTc intervals. One patient on 300 mg who was hypertensive and on other medications that may prolong QTc, had mildly prolonged QTc. However this was not clinically significant. CONCLUSION: This study of subjects on high dose venlafaxine (mean 346.15 mg; range 225-525 mg) did not demonstrate any clinical or statistically significant effects on electrocardiogram (ECG) parameters including PR, QT, QRSD and QTc interval. Copyright 2007 John Wiley & Sons, Ltd.
OBJECTIVE: To assess cardiovascular safety profile of high dose Venlafaxine XL in patients with major depression. METHOD: Effects of high dose venlafaxine (mean 346.15 mg;) on the cardiovascular system in 37 patients with major depressive disorder were evaluated: BP, ECG (PR, QT, QRSD and QTc intervals) and heart rate. RESULTS: 12.5% of patients developed hypertension after starting treatment with venlafaxine. There was an association between heart rate and the dose of venlafaxine although not statistically significant. There was no association between dose of venlafaxine and PR, QT, QRSD and QTc intervals. One patient on 300 mg who was hypertensive and on other medications that may prolong QTc, had mildly prolonged QTc. However this was not clinically significant. CONCLUSION: This study of subjects on high dose venlafaxine (mean 346.15 mg; range 225-525 mg) did not demonstrate any clinical or statistically significant effects on electrocardiogram (ECG) parameters including PR, QT, QRSD and QTc interval. Copyright 2007 John Wiley & Sons, Ltd.
Authors: Lauren M Behlke; Eric J Lenze; Vy Pham; J Philip Miller; Timothy W Smith; Yasmina Saade; Jordan F Karp; Charles F Reynolds; Daniel M Blumberger; Cristiana Stefan; Benoit H Mulsant Journal: J Clin Psychopharmacol Date: 2020 Nov/Dec Impact factor: 3.118