Literature DB >> 1739689

Survey of the contamination of eyedrops of hospital inpatients and recommendations for the changing of current practice in eyedrop dispensing.

J D Stevens1, M M Matheson.   

Abstract

Topical ophthalmic medications used on the ward and from the outpatient area have been taken and cultured for potential bacterial contamination in the laboratory. We examined 143 bottles used by patients who had had routine cataract surgery and trabeculectomy. We also examined for bacterial contamination 216 bottles of eyedrops used in the outpatient area of the hospital. No contamination was found in the postoperative eyedrops, but five bottles were contaminated from the outpatient area (2.3%). The bacterial growth from outpatient drops was of the same order of magnitude as in previous studies. The practice in the UK for postoperative eyedrops to be discarded and fresh, separate bottles to take home is discussed. We recommend that this practice be changed so that the postoperative drops used for 72 hours or less are taken home.

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Year:  1992        PMID: 1739689      PMCID: PMC504146          DOI: 10.1136/bjo.76.1.36

Source DB:  PubMed          Journal:  Br J Ophthalmol        ISSN: 0007-1161            Impact factor:   4.638


  11 in total

1.  Contamination of dropper bottles with tear fluid in an ophthalmic outpatient clinic.

Authors:  G W Aylward; R S Wilson
Journal:  Br Med J (Clin Res Ed)       Date:  1987-06-20

2.  [Effect of preservatives on the survival of Staphylococcus aureus and Pseudomonas aeruginosa in eyedrops containing antibiotics].

Authors:  Z Olszewski; J Michalewska; H Krutul; L Scimborska
Journal:  Acta Pol Pharm       Date:  1976       Impact factor: 0.330

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Authors:  C T Coad; M S Osato; K R Wilhelmus
Journal:  Am J Ophthalmol       Date:  1984-11       Impact factor: 5.258

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Authors:  D J McIntyre
Journal:  Ophthalmic Surg       Date:  1984-06

5.  Bacterial contamination of drops and dropper tips of in-use multidose eye drop bottles.

Authors:  G Høvding; H Sjursen
Journal:  Acta Ophthalmol (Copenh)       Date:  1982-04

6.  A note on the contamination of eye-drops following use by hospital out-patients.

Authors:  J L Ford; M W Brown; P B Hunt
Journal:  J Clin Hosp Pharm       Date:  1985-06

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Authors:  B Aslund; O T Olson; E Sandell
Journal:  Acta Pharm Suec       Date:  1978

8.  Prolonged antibacterial activity of a fluorescein-anesthetic solution.

Authors:  H L Stewart
Journal:  Arch Ophthalmol       Date:  1972-10

9.  Microbial keratitis associated with contaminated ocular medications.

Authors:  O D Schein; P J Wasson; S A Boruchoff; K R Kenyon
Journal:  Am J Ophthalmol       Date:  1988-04-15       Impact factor: 5.258

10.  Serratia keratitis transmitted by contaminated eyedroppers.

Authors:  W C Templeton; R A Eiferman; J W Snyder; J C Melo; M J Raff
Journal:  Am J Ophthalmol       Date:  1982-06       Impact factor: 5.258

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  9 in total

1.  Irreversible electroporation for microbial control of drugs in solution.

Authors:  Alex Golberg; Michael Belkin; Boris Rubinsky
Journal:  AAPS PharmSciTech       Date:  2009-07-02       Impact factor: 3.246

2.  "In use" expiry date for eyedrops.

Authors:  S Rauz; B J Moate; A S Jacks; N Cumberland; J A Govan
Journal:  Br J Ophthalmol       Date:  1996-03       Impact factor: 4.638

3.  Microbial Contamination of Preservative-Free Artificial Tears Based on Instillation Techniques.

Authors:  Jee-Hye Lee; Min-Ji Kang; Ha-Eun Sim; Je-Hyung Hwang
Journal:  Pathogens       Date:  2022-05-18

4.  Bacterial contamination of ophthalmic solutions used in an extended care facility.

Authors:  Danny H-Kauffmann Jokl; Gary P Wormser; Neil S Nichols; Marisa A Montecalvo; Carol L Karmen
Journal:  Br J Ophthalmol       Date:  2007-05-02       Impact factor: 4.638

5.  Microbial contamination of medications used to treat glaucoma.

Authors:  O Geyer; E J Bottone; S M Podos; R A Schumer; P A Asbell
Journal:  Br J Ophthalmol       Date:  1995-04       Impact factor: 4.638

6.  Microbial contamination of glaucoma eyedrops used by patients compared with ocular medications used in the hospital.

Authors:  Barbara Teuchner; Julia Wagner; Nikolaos E Bechrakis; Dorothea Orth-Höller; Markus Nagl
Journal:  Medicine (Baltimore)       Date:  2015-02       Impact factor: 1.889

7.  Bacterial Contamination of Multi-dose Eye Drops at Ophthalmology Department, University of Gondar, Northwest Ethiopia.

Authors:  Asegedech Tsegaw; Asamere Tsegaw; Tefera Abula; Yared Assefa
Journal:  Middle East Afr J Ophthalmol       Date:  2017 Apr-Jun

8.  Contamination of multi dose eyedrops in the intra and perioperative context.

Authors:  Tristan Daehn; Andreas Schneider; Johannes Knobloch; Olaf J C Hellwinkel; Martin Stephan Spitzer; Robert Kromer
Journal:  Sci Rep       Date:  2021-10-13       Impact factor: 4.379

9.  Microbial Cross-contamination in Multidose Eyedrops: The Impact of Instillation Angle and Bottle Geometry.

Authors:  Alexandre Xavier da Costa; Maria Cecilia Zorat Yu; Denise de Freitas; Priscila Cardoso Cristovam; Lauren C LaMonica; Vagner Rogerio Dos Santos; José Alvaro Pereira Gomes
Journal:  Transl Vis Sci Technol       Date:  2020-06-05       Impact factor: 3.283

  9 in total

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