PURPOSE: We sought to determine trends in the prevalence, awareness, treatment and control of high low-density lipoprotein (LDL) cholesterol among U.S. adults. METHODS: Data from 6497 participants of the Third National Health and Nutrition Examination Survey (NHANES) conducted in 1988-1994 and 5626 participants of NHANES 1999-2004 were compared. High LDL cholesterol was defined using risk-specific cut-points from the National Cholesterol Education Program's Adult Treatment Panel III guidelines. RESULTS: The age-standardized percentage of U.S. adults with high LDL cholesterol was 26.6% in 1988-1994 and 25.3% in 1999-2004 (P = 0.28). Between 1988-1994 and 1999-2004, awareness increased from 39.2% to 63.0%, and use of pharmacologic lipid-lowering treatment increased from 11.7% to 40.8% (each p < 0.001). LDL cholesterol control increased from 4.0% to 25.1% among those with high LDL cholesterol (p < 0.001). In 1999-2004, rates of LDL cholesterol control were lower among adults ages 20-49 years compared with those age 65 years or older (13.9% vs. 30.3%; p < 0.001); non-Hispanic blacks and Mexican-Americans compared with non-Hispanic whites (17.2% and 16.5% vs. 26.9%, respectively; p = 0.05 and p = 0.008); and males compared with females (22.6% vs. 28.0%; p = 0.01). CONCLUSIONS: Continued efforts are needed to lower the burden of high LDL cholesterol and increase LDL cholesterol control, especially among populations with low control rates.
PURPOSE: We sought to determine trends in the prevalence, awareness, treatment and control of high low-density lipoprotein (LDL) cholesterol among U.S. adults. METHODS: Data from 6497 participants of the Third National Health and Nutrition Examination Survey (NHANES) conducted in 1988-1994 and 5626 participants of NHANES 1999-2004 were compared. High LDL cholesterol was defined using risk-specific cut-points from the National Cholesterol Education Program's Adult Treatment Panel III guidelines. RESULTS: The age-standardized percentage of U.S. adults with high LDL cholesterol was 26.6% in 1988-1994 and 25.3% in 1999-2004 (P = 0.28). Between 1988-1994 and 1999-2004, awareness increased from 39.2% to 63.0%, and use of pharmacologic lipid-lowering treatment increased from 11.7% to 40.8% (each p < 0.001). LDL cholesterol control increased from 4.0% to 25.1% among those with high LDL cholesterol (p < 0.001). In 1999-2004, rates of LDL cholesterol control were lower among adults ages 20-49 years compared with those age 65 years or older (13.9% vs. 30.3%; p < 0.001); non-Hispanic blacks and Mexican-Americans compared with non-Hispanic whites (17.2% and 16.5% vs. 26.9%, respectively; p = 0.05 and p = 0.008); and males compared with females (22.6% vs. 28.0%; p = 0.01). CONCLUSIONS: Continued efforts are needed to lower the burden of high LDL cholesterol and increase LDL cholesterol control, especially among populations with low control rates.
Authors: Huifen Wang; Lyn M Steffen; David R Jacobs; Xia Zhou; Henry Blackburn; Alan K Berger; Kristian B Filion; Russell V Luepker Journal: Am J Epidemiol Date: 2011-01-27 Impact factor: 4.897
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Authors: Alan S Go; Dariush Mozaffarian; Véronique L Roger; Emelia J Benjamin; Jarett D Berry; Michael J Blaha; Shifan Dai; Earl S Ford; Caroline S Fox; Sheila Franco; Heather J Fullerton; Cathleen Gillespie; Susan M Hailpern; John A Heit; Virginia J Howard; Mark D Huffman; Suzanne E Judd; Brett M Kissela; Steven J Kittner; Daniel T Lackland; Judith H Lichtman; Lynda D Lisabeth; Rachel H Mackey; David J Magid; Gregory M Marcus; Ariane Marelli; David B Matchar; Darren K McGuire; Emile R Mohler; Claudia S Moy; Michael E Mussolino; Robert W Neumar; Graham Nichol; Dilip K Pandey; Nina P Paynter; Matthew J Reeves; Paul D Sorlie; Joel Stein; Amytis Towfighi; Tanya N Turan; Salim S Virani; Nathan D Wong; Daniel Woo; Melanie B Turner Journal: Circulation Date: 2013-12-18 Impact factor: 29.690
Authors: Richard M Zweifler; Leslie A McClure; Virginia J Howard; Mary Cushman; Martha K Hovater; Monika M Safford; George Howard; David C Goff Journal: Neuroepidemiology Date: 2011-08-05 Impact factor: 3.282