| Literature DB >> 17395259 |
Elisa Giovannetti1, Dewa G Ugrasena, Eddy Supriyadi, Laura Vroling, Antonino Azzarello, Desiree de Lange, Godefridus J Peters, Anjo J P Veerman, Jacqueline Cloos.
Abstract
Genetic variations in the polymorphic tandem repeat sequence of the enhancer region of the thymidylate synthase promoter (TSER), as well as in methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, influence methotrexate sensitivity. We studied these polymorphisms in children with acute lymphoblastic leukaemia (ALL) and in subjects without malignancy in Indonesia and Holland. The frequencies of TT and CT genotypes were two-fold higher in Dutch children. The TSER 3R/3R repeat was three-fold more frequent in the Indonesian children, while the 2R/2R repeat was only 1% compared to 21% in the Dutch children. No differences of these polymorphisms were found between ALL cells and normal blood cells, indicating an ethnic rather than leukemic origin. These results may have implications for treatment of Indonesian children with ALL.Entities:
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Year: 2007 PMID： 17395259 DOI： 10.1016/j.leukres.2007.02.011
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156