OBJECTIVE: To describe the characteristics of patients with multidrug-resistant tuberculosis (MDR-TB), a descriptive prospective study was carried out applying a combination of exhaustive conventional epidemiology with molecular genotyping. SETTING: All patients diagnosed with MDR-TB in Galicia, Spain, between 1998 and 2004 were included in the study. DESIGN: Of 9895 diagnosed cases of TB, 58 were MDR-TB (0.59%). The site of disease was pulmonary in 56 cases and 46 were smear-positive. Only two cases were co-infected with the human immunodeficiency virus (HIV) and seven were immigrants. Twenty-five (43%) had received previous TB treatment. These cases presented more risk factors for treatment default and a lower frequency of contact with cases of MDR-TB. RESULTS: Genotyping analysis was performed in 57 patients, showing evidence of four clusters (30 patients, 52.6%), each with identical genetic patterns. The patients included in the clusters were younger, and most had primary forms or had had contact with another case of MDR-TB, especially in hospital. Neither the Beijing/W nor the B strain was identified. CONCLUSION: There is a low prevalence of MDR-TB in Galicia. Unlike previous studies, there was a high rate of transmissibility, including nosocomial transmission. Transmission is not associated with HIV or previously reported strains with a high capacity for transmission.
OBJECTIVE: To describe the characteristics of patients with multidrug-resistant tuberculosis (MDR-TB), a descriptive prospective study was carried out applying a combination of exhaustive conventional epidemiology with molecular genotyping. SETTING: All patients diagnosed with MDR-TB in Galicia, Spain, between 1998 and 2004 were included in the study. DESIGN: Of 9895 diagnosed cases of TB, 58 were MDR-TB (0.59%). The site of disease was pulmonary in 56 cases and 46 were smear-positive. Only two cases were co-infected with the human immunodeficiency virus (HIV) and seven were immigrants. Twenty-five (43%) had received previous TB treatment. These cases presented more risk factors for treatment default and a lower frequency of contact with cases of MDR-TB. RESULTS: Genotyping analysis was performed in 57 patients, showing evidence of four clusters (30 patients, 52.6%), each with identical genetic patterns. The patients included in the clusters were younger, and most had primary forms or had had contact with another case of MDR-TB, especially in hospital. Neither the Beijing/W nor the B strain was identified. CONCLUSION: There is a low prevalence of MDR-TB in Galicia. Unlike previous studies, there was a high rate of transmissibility, including nosocomial transmission. Transmission is not associated with HIV or previously reported strains with a high capacity for transmission.
Authors: T Jagielski; A Brzostek; A van Belkum; J Dziadek; E Augustynowicz-Kopeć; Z Zwolska Journal: Eur J Clin Microbiol Infect Dis Date: 2014-07-20 Impact factor: 3.267
Authors: Timothy F Brewer; Howard W Choi; Carlos Seas; Fiorella Krapp; Carlos Zamudio; Lena Shah; Antonio Ciampi; S Jody Heymann; Eduardo Gotuzzo Journal: PLoS One Date: 2011-10-14 Impact factor: 3.240
Authors: John Z Metcalfe; Elizabeth Y Kim; S-Y Grace Lin; Adithya Cattamanchi; Peter Oh; Jennifer Flood; Philip C Hopewell; Midori Kato-Maeda Journal: Emerg Infect Dis Date: 2010-09 Impact factor: 6.883
Authors: James Johnston; Andrew Admon; Amir Ibrahim; Kevin Elwood; Patrick Tang; Victoria Cook; Mark Fitzgerald Journal: BMC Infect Dis Date: 2012-10-22 Impact factor: 3.090