Literature DB >> 1739463

Interaction of free and synaptic vesicle-bound synapsin I with F-actin.

F Benfenati1, F Valtorta, E Chieregatti, P Greengard.   

Abstract

Synapsin I is a neuron-specific phosphoprotein that binds to small synaptic vesicles and F-actin in a phosphorylation-dependent fashion. We have found that dephosphorylated synapsin I induces a dose-dependent increase in the number of actin filaments, which at high ionic strength is abolished by synapsin I phosphorylation. The increase in filament number appears to be due to a nucleating effect of synapsin I and not to a barbed-end capping/severing activity. Synaptic vesicle-bound synapsin I was as effective as free synapsin I in increasing the number of filaments. These data support the view that synapsin I is involved in the regulation of the dynamics of the actin-based network during the exo-endocytotic cycle.

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Year:  1992        PMID： 1739463     DOI： 10.1016/0896-6273(92)90303-u

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  35 in total

Review 1.  Synapsins as regulators of neurotransmitter release.

Authors:  S Hilfiker; V A Pieribone; A J Czernik; H T Kao; G J Augustine; P Greengard
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1999-02-28       Impact factor: 6.237

Review 2.  Protein-protein interactions and protein modules in the control of neurotransmitter release.

Authors:  F Benfenati; F Onofri; S Giovedí
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1999-02-28       Impact factor: 6.237

3.  Modulation of actin filament behavior by GAP-43 (neuromodulin) is dependent on the phosphorylation status of serine 41, the protein kinase C site.

Authors:  Q He; E W Dent; K F Meiri
Journal:  J Neurosci       Date:  1997-05-15       Impact factor: 6.167

4.  Structural domains involved in the regulation of transmitter release by synapsins.

Authors:  Sabine Hilfiker; Fabio Benfenati; Frédéric Doussau; Angus C Nairn; Andrew J Czernik; George J Augustine; Paul Greengard
Journal:  J Neurosci       Date:  2005-03-09       Impact factor: 6.167

Review 5.  A Fresh Look at the Structure, Regulation, and Functions of Fodrin.

Authors:  Jamuna S Sreeja; Rince John; Dhrishya Dharmapal; Rohith Kumar Nellikka; Suparna Sengupta
Journal:  Mol Cell Biol       Date:  2020-08-14       Impact factor: 4.272

Review 6.  The role of synapsins in neuronal development.

Authors:  Eugenio F Fornasiero; Dario Bonanomi; Fabio Benfenati; Flavia Valtorta
Journal:  Cell Mol Life Sci       Date:  2009-12-25       Impact factor: 9.261

7.  Synaptic vesicle movements monitored by fluorescence recovery after photobleaching in nerve terminals stained with FM1-43.

Authors:  A W Henkel; L L Simpson; R M Ridge; W J Betz
Journal:  J Neurosci       Date:  1996-06-15       Impact factor: 6.167

8.  Identification, expression, and crystallization of the protease-resistant conserved domain of synapsin I.

Authors:  C R Wang; L Esser; C S Smagula; T C Südhof; J Deisenhofer
Journal:  Protein Sci       Date:  1997-10       Impact factor: 6.725

9.  Neurotrophins stimulate phosphorylation of synapsin I by MAP kinase and regulate synapsin I-actin interactions.

Authors:  J N Jovanovic; F Benfenati; Y L Siow; T S Sihra; J S Sanghera; S L Pelech; P Greengard; A J Czernik
Journal:  Proc Natl Acad Sci U S A       Date:  1996-04-16       Impact factor: 11.205

10.  Ca2+-independent activation of Ca2+/calmodulin-dependent protein kinase II bound to the C-terminal domain of CaV2.1 calcium channels.

Authors:  Venkat G Magupalli; Sumiko Mochida; Jin Yan; Xin Jiang; Ruth E Westenbroek; Angus C Nairn; Todd Scheuer; William A Catterall
Journal:  J Biol Chem       Date:  2012-12-19       Impact factor: 5.157
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