| Literature DB >> 17393952 |
R Michael Williams1, David W Moskowitz.
Abstract
A 48-year-old African-American woman with both sickle cell anemia and chronic pain was treated with a hydrophobic angiotensin I-converting enzyme (ACE) inhibitor. This resulted in the complete resolution of her pain. When the ACE inhibitor was deliberately stopped, her pain recurred, only to cease again after the ACE inhibitor was deliberately resumed. The activation of ACE may be an early step in the arterial vaso-occlusion typical of sickle cell disease.Entities:
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Year: 2007 PMID： 17393952 PMCID： PMC2569632
Source DB: PubMed Journal: J Natl Med Assoc ISSN： 0027-9684 Impact factor: 1.798