Literature DB >> 17393658

9-epi-Viridiol, a novel cytotoxic furanosteroid from soil fungus Trichoderma virens.

Preecha Phuwapraisirisan1, Jakaphan Rangsan, Pongpun Siripong, Santi Tip-Pyang.   

Abstract

A novel furanosteroid named 9-epi-viridiol (1), along with viridiol (2) and mevalonic acid (3), was isolated from Trichoderma virens. The structure of 1 was verified by combined spectroscopic data (COSY, HSQC, HMBC and NOESY) to be a C-9 epimer of viridiol. 9-epi-Viridiol exhibited cytotoxicity towards HeLa and KB cells with IC50 values of 19 and 50 microg mL(-1), respectively.

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Year:  2006        PMID: 17393658     DOI: 10.1080/14786410601101969

Source DB:  PubMed          Journal:  Nat Prod Res        ISSN: 1478-6419            Impact factor:   2.861


  1 in total

1.  In Vitro Effects of Fungal Phytotoxins on Cancer Cell Viability: First Insight into Structure Activity Relationship of a Potent Metabolite of Cochliobolus australiensis Radicinin.

Authors:  Veronique Mathieu; Stefano Superchi; Marco Masi; Patrizia Scafato; Alexander Kornienko; Antonio Evidente
Journal:  Toxins (Basel)       Date:  2022-07-29       Impact factor: 5.075

  1 in total

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