BACKGROUND: About 40% of the patients with Parkinson's disease (PD) have depressive symptoms, either major depression (MD) or subthreshold depression. Depression was found to be associated with age and age at onset of PD, female gender, more severe parkinsonism, in particular with left-sided and akinetic-rigid symptoms, more functional impairment and cognitive impairment.However, the findings are inconsistent and partly contradictory and most of the studies focused on major depression in PD without dementia. The aim of this study was to examine the relationship between subthreshold depression and other clinical features in 538 PD patients with dementia but without MD drawn from a randomized, placebo-controlled multicentre trial of rivastigmine in PD. RESULTS:One hundred and sixteen patients (21%) had subthreshold depression. Depression was associated with a younger age and age at onset and female gender, but not with severity of parkinsonism, cognition or activities of daily living or laterality of motor symptoms. However, in male patients, an association between depression and left-sided parkinsonism was found. CONCLUSION: In contrast to previous findings in PD patients with major depression but without dementia, we found no relationship between subthreshold depression and other clinical symptoms in patients with PDD. Copyright (c) 2007 John Wiley & Sons, Ltd.
RCT Entities:
BACKGROUND: About 40% of the patients with Parkinson's disease (PD) have depressive symptoms, either major depression (MD) or subthreshold depression. Depression was found to be associated with age and age at onset of PD, female gender, more severe parkinsonism, in particular with left-sided and akinetic-rigid symptoms, more functional impairment and cognitive impairment.However, the findings are inconsistent and partly contradictory and most of the studies focused on major depression in PD without dementia. The aim of this study was to examine the relationship between subthreshold depression and other clinical features in 538 PDpatients with dementia but without MD drawn from a randomized, placebo-controlled multicentre trial of rivastigmine in PD. RESULTS: One hundred and sixteen patients (21%) had subthreshold depression. Depression was associated with a younger age and age at onset and female gender, but not with severity of parkinsonism, cognition or activities of daily living or laterality of motor symptoms. However, in male patients, an association between depression and left-sided parkinsonism was found. CONCLUSION: In contrast to previous findings in PDpatients with major depression but without dementia, we found no relationship between subthreshold depression and other clinical symptoms in patients with PDD. Copyright (c) 2007 John Wiley & Sons, Ltd.
Authors: Daniel A Nation; Heather L Katzen; Spyridon Papapetropoulos; Blake K Scanlon; Bonnie E Levin Journal: Int J Geriatr Psychiatry Date: 2009-09 Impact factor: 3.485
Authors: Pablo Martinez-Martin; Cristian Falup Pecurariu; Per Odin; Jacobus J van Hilten; Angelo Antonini; Jose M Rojo-Abuin; Vanderci Borges; Claudia Trenkwalder; Dag Aarsland; David J Brooks; Kallol Ray Chaudhuri Journal: J Neurol Date: 2012-01-12 Impact factor: 4.849
Authors: Aline Schönenberg; Hannah M Zipprich; Ulrike Teschner; Julian Grosskreutz; Otto W Witte; Tino Prell Journal: Health Qual Life Outcomes Date: 2021-03-25 Impact factor: 3.186