Literature DB >> 17393334

Oxidative DNA damage and antioxidant activity in patients with inflammatory bowel disease.

Yildiz Dincer1, Yusuf Erzin, Solen Himmetoglu, Kezban Nur Gunes, Kadir Bal, Tülay Akcay.   

Abstract

Chronic inflammation may contribute to cancer risk through the accumulation of specific products as a result of DNA damage. Endogenous antioxidant enzymes prevent the formation of these harmful products. Oxidative DNA damage and endogenous antioxidant defense were determined in patients with inflammatory bowel disease (IBD). Plasma levels of 8-hydroxydeoxyguanosine (8-OHdG) and nitric oxide (NO) and plasma activities of glutathione peroxidase (G-Px) and superoxide dismutase (SOD) were determined in patients with IBD by ELISA and spectrophotometric assay, respectively. Plasma levels of 8-OHdG, SOD, and G-Px activity were found to be increased in the patient group compared to the control group (P < 0.02, P < 0.001, and P < 0.001, respectively), whereas NO was unchanged. 8-OHdG level was found to be weakly correlated with age, NO, and SOD. The results show increased DNA damage in patients with IBD. This may explain the increased risk of developing colon cancer in these patients.

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Year:  2007        PMID： 17393334     DOI： 10.1007/s10620-006-9386-8

Source DB:  PubMed          Journal:  Dig Dis Sci        ISSN： 0163-2116            Impact factor:   3.487


  42 in total

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Review 4.  Influence of oxygen radical injury on DNA methylation.

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Authors:  Darren N Seril; Jie Liao; Guang-Yu Yang; Chung S Yang
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Review 10.  Novel aspects of macromolecular repair and relationship to human disease.

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  26 in total

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4.  Tumor suppressor function of the plasma glutathione peroxidase gpx3 in colitis-associated carcinoma.

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7.  Inhibition of APE1/Ref-1 Redox Signaling Alleviates Intestinal Dysfunction and Damage to Myenteric Neurons in a Mouse Model of Spontaneous Chronic Colitis.

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8.  A longer adaptation period to a functional amino acid-supplemented diet improves growth performance and immune status of Salmonella Typhimurium-challenged pigs.

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9.  Functional amino acid supplementation, regardless of dietary protein content, improves growth performance and immune status of weaned pigs challenged with Salmonella Typhimurium.

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10.  Nuclear oxidative damage correlates with poor survival in colorectal cancer.

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