Literature DB >> 17391008

One-step synthesis of oxazoline and dihydrooxazine libraries.

Priyanka Chaudhry1, Frank Schoenen, Benjamin Neuenswander, Gerald H Lushington, Jeffrey Aubé.   

Abstract

The reactions of 1,2- and 1,3-hydroxyalkyl azides and aldehydes in the presence of Lewis acid result in the one-step construction of oxazolines and dihydrooxazines, respectively. The reaction was adapted to parallel synthesis using a polymer-bound phosphine to scavenge excess hydroxyalkyl azide. Thus, a 60-member library of various disubstituted oxazolines and di- and trisubstituted dihydrooxazines was generated.

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Year:  2007        PMID： 17391008      PMCID： PMC2539067          DOI： 10.1021/cc060159t

Source DB:  PubMed          Journal:  J Comb Chem        ISSN： 1520-4766


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