Literature DB >> 17390147

Anti-leishmania activity of semi-purified fraction of Jacaranda puberula leaves.

L F D Passero1, A A Castro, T Y Tomokane, M J Kato, T F Paulinetti, C E P Corbett, M D Laurenti.   

Abstract

The crude methanolic extract from leaves of Jacaranda puberula showed activity against Leishmania (Leishmania) amazonensis. The extract presented active against promastigote forms with an inhibitory concentration 50% (IC(50)) value of 88.0 mug/ml, but only moderated activity against amastigote forms; however in higher concentrations the extract showed cytotoxic effects. The bio-guided chromatographic fractionation the crude methanolic extract against amastigotes yielded a fraction with an IC(50) value of 14.0 mug/ml (without cytotoxic activity) in relation to the crude extract (IC(50) value, 359.0 microg/ml). These data indicate that J. puberula leaves contain active compounds, which should be further investigated for the development of new potential drugs against cutaneous leishmaniasis.

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Year:  2007        PMID： 17390147     DOI： 10.1007/s00436-007-0530-y

Source DB:  PubMed          Journal:  Parasitol Res        ISSN： 0932-0113            Impact factor:   2.289


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