Joseph E Thomas1, Nora Lee, Paul D Thompson. 1. Department of Internal Medicine, School of Medicine, University of Connecticut, Farmington, Conn., USA. drjethomas@yahoo.com
Abstract
BACKGROUND: Statins inhibit the production of 2,3-dimethoxy,5-methyl,6-polyisoprene parabenzoquinone also known as ubiquinone or coenzyme Q10 (CoQ10), which is required for mitochondrial electron transport. Idiopathic or primary CoQ10 deficiencies have been known to cause mitochondrial encephalomyopathy. METHODS: We present the case of a patient with mitochondrial syndrome, consisting of mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS), whose symptoms were temporally related to statin therapy. CONCLUSION: Statins may provoke symptoms related to MELAS in susceptible individuals. 2007 S. Karger AG, Basel
BACKGROUND: Statins inhibit the production of 2,3-dimethoxy,5-methyl,6-polyisoprene parabenzoquinone also known as ubiquinone or coenzyme Q10 (CoQ10), which is required for mitochondrial electron transport. Idiopathic or primary CoQ10 deficiencies have been known to cause mitochondrial encephalomyopathy. METHODS: We present the case of a patient with mitochondrial syndrome, consisting of mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS), whose symptoms were temporally related to statin therapy. CONCLUSION: Statins may provoke symptoms related to MELAS in susceptible individuals. 2007 S. Karger AG, Basel
Authors: Sylvie Callegari; Philip A Gregory; Matthew J Sykes; Jennifer Bellon; Stuart Andrews; Ross A McKinnon; Miguel A de Barros Lopes Journal: PLoS Genet Date: 2012-06-14 Impact factor: 5.917