Literature DB >> 17389748

The macrophage migration inhibitory factor-glucocorticoid dyad: regulation of inflammation and immunity.

Harry Flaster1, Jürgen Bernhagen, Thierry Calandra, Richard Bucala.   

Abstract

The cytokine macrophage migration inhibitory factor (MIF) occupies a unique position in physiology by its ability to directly regulate the immunosuppressive actions of glucocorticoids. We review herein the interactions between MIF and glucocorticoids within the immune system and discuss the relevance of the MIF-glucocorticoid regulatory dyad in physiology and immunopathology. Therapeutic antagonism of MIF may be an effective approach for steroid-sparing therapies in patients with refractory autoimmune or inflammatory diseases.

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Year:  2007        PMID： 17389748     DOI： 10.1210/me.2007-0065

Source DB:  PubMed          Journal:  Mol Endocrinol        ISSN： 0888-8809


  90 in total

1.  Assessment of the involvement of the macrophage migration inhibitory factor-glucocorticoid regulatory dyad in the expression of matrix metalloproteinase-2 during periodontitis.

Authors:  Josefine Hirschfeld; Mohammed Howait; Alexandru Movila; Marijo Parčina; Isabelle Bekeredjian-Ding; James Deschner; Søren Jepsen; Toshihisa Kawai
Journal:  Eur J Oral Sci       Date:  2017-08-04       Impact factor: 2.612

2.  Macrophage migration inhibitory factor: a downregulator of early T cell-dependent IFN-gamma responses in Plasmodium chabaudi adami (556 KA)-infected mice.

Authors:  Diane Tshikudi Malu; Benoit Bélanger; François Desautels; Karine Kelendji; Esther Dalko; Jaime Sanchez-Dardon; Lin Leng; Richard Bucala; Abhay R Satoskar; Tatiana Scorza
Journal:  J Immunol       Date:  2011-04-25       Impact factor: 5.422

Review 3.  D-dopachrome tautomerase (D-DT or MIF-2): doubling the MIF cytokine family.

Authors:  Melanie Merk; Robert A Mitchell; Stefan Endres; Richard Bucala
Journal:  Cytokine       Date:  2012-04-14       Impact factor: 3.861

Review 4.  Macrophage migration inhibitory factor (MIF): a promising biomarker.

Authors:  Gerrit Grieb; Melanie Merk; Jürgen Bernhagen; Richard Bucala
Journal:  Drug News Perspect       Date:  2010-05

5.  Macrophage migration inhibitory factor deficiency protects pancreatic islets from cytokine-induced apoptosis in vitro.

Authors:  I Stojanovic; T Saksida; I Nikolic; F Nicoletti; S Stosic-Grujicic
Journal:  Clin Exp Immunol       Date:  2012-08       Impact factor: 4.330

6.  The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF).

Authors:  Melanie Merk; Swen Zierow; Lin Leng; Rituparna Das; Xin Du; Wibke Schulte; Juan Fan; Hongqi Lue; Yibang Chen; Huabao Xiong; Frederic Chagnon; Jürgen Bernhagen; Elias Lolis; Gil Mor; Olivier Lesur; Richard Bucala
Journal:  Proc Natl Acad Sci U S A       Date:  2011-08-04       Impact factor: 11.205

7.  Novel half-life extended anti-MIF nanobodies protect against endotoxic shock.

Authors:  Amanda Sparkes; Patrick De Baetselier; Lea Brys; Inês Cabrito; Yann G-J Sterckx; Steve Schoonooghe; Serge Muyldermans; Geert Raes; Richard Bucala; Peter Vanlandschoot; Jo A Van Ginderachter; Benoît Stijlemans
Journal:  FASEB J       Date:  2018-01-25       Impact factor: 5.191

Review 8.  MIF family cytokines in cardiovascular diseases and prospects for precision-based therapeutics.

Authors:  Pathricia V Tilstam; Dake Qi; Lin Leng; Lawrence Young; Richard Bucala
Journal:  Expert Opin Ther Targets       Date:  2017-07       Impact factor: 6.902

Review 9.  Neuroendocrine-immune interactions in rheumatoid arthritis: mechanisms of glucocorticoid resistance.

Authors:  Marni N Silverman; Esther M Sternberg
Journal:  Neuroimmunomodulation       Date:  2008-07-29       Impact factor: 2.492

10.  Independent roles of macrophage migration inhibitory factor and endogenous, but not exogenous glucocorticoids in regulating leukocyte trafficking.

Authors:  Julia L Gregory; Pam Hall; Michelle Leech; Eric F Morand; Michael J Hickey
Journal:  Microcirculation       Date:  2009-11       Impact factor: 2.628
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