BACKGROUND: The hypothesis of carotenoids having a preventive role in cognitive impairment is suggested by their antioxidant properties. METHODS: We examined, in a cross-sectional analysis, the relationship between cognitive performance (assessed by the Mini-Mental State Examination, Trail Making Test Part B, Digit Symbol Substitution, Finger Tapping Test, and Word Fluency Test) and different plasma carotenoids (lutein, zeaxanthin, beta-cryptoxanthin, lycopene, alpha-carotene, and trans-beta-carotene and cis-beta-carotene) in a healthy elderly population (the EVA,"Etude du Vieillissement Artériel," study; n = 589, age = 73.5 +/- 3 years). RESULTS: Logistic regression showed that participants with the lowest cognitive functioning (<25th percentile) had a higher probability of having low levels of specific plasma carotenoids (<1st quartile): lycopene and zeaxanthin. For zeaxanthin, odds ratios (ORs) were as follows: OR(DSS) = 1.97 (95% confidence interval [CI] = 1.21-3.20), OR(FTT) = 1.70 (CI = 1.05-2.74), and OR(WFT) = 1.82 (CI = 1.08-3.07); for lycopene, OR(DSS) = 1.93 (CI = 1.20-3.12) and OR(TMTB) = 1.64 (CI = 1.04-2.59). CONCLUSION: Even if it is not possible to affirm if these low levels of carotenoids precede or are the consequence of cognitive impairment, our results suggest that low carotenoid levels could play a role in cognitive impairment. The biological significance of our findings needs further research.
BACKGROUND: The hypothesis of carotenoids having a preventive role in cognitive impairment is suggested by their antioxidant properties. METHODS: We examined, in a cross-sectional analysis, the relationship between cognitive performance (assessed by the Mini-Mental State Examination, Trail Making Test Part B, Digit Symbol Substitution, Finger Tapping Test, and Word Fluency Test) and different plasma carotenoids (lutein, zeaxanthin, beta-cryptoxanthin, lycopene, alpha-carotene, and trans-beta-carotene and cis-beta-carotene) in a healthy elderly population (the EVA,"Etude du Vieillissement Artériel," study; n = 589, age = 73.5 +/- 3 years). RESULTS: Logistic regression showed that participants with the lowest cognitive functioning (<25th percentile) had a higher probability of having low levels of specific plasma carotenoids (<1st quartile): lycopene and zeaxanthin. For zeaxanthin, odds ratios (ORs) were as follows: OR(DSS) = 1.97 (95% confidence interval [CI] = 1.21-3.20), OR(FTT) = 1.70 (CI = 1.05-2.74), and OR(WFT) = 1.82 (CI = 1.08-3.07); for lycopene, OR(DSS) = 1.93 (CI = 1.20-3.12) and OR(TMTB) = 1.64 (CI = 1.04-2.59). CONCLUSION: Even if it is not possible to affirm if these low levels of carotenoids precede or are the consequence of cognitive impairment, our results suggest that low carotenoid levels could play a role in cognitive impairment. The biological significance of our findings needs further research.
Authors: Marwa Ahmed Abass; Shereen Ahmed Elkhateeb; Samia Adel Abd El-Baset; Asmaa Alhosiny Kattaia; Eman Mosallam Mohamed; Hebatallah Husseini Atteia Journal: Environ Sci Pollut Res Int Date: 2016-04-22 Impact factor: 4.223
Authors: Correne A DeCarlo; Holly A Tuokko; Dorothy Williams; Roger A Dixon; Stuart W S MacDonald Journal: Ageing Res Rev Date: 2014-09-30 Impact factor: 10.895
Authors: Rohini Vishwanathan; Alessandro Iannaccone; Tammy M Scott; Stephen B Kritchevsky; Barbara J Jennings; Giovannella Carboni; Gina Forma; Suzanne Satterfield; Tamara Harris; Karen C Johnson; Wolfgang Schalch; Lisa M Renzi; Caterina Rosano; Elizabeth J Johnson Journal: Age Ageing Date: 2014-01-15 Impact factor: 10.668
Authors: Luigi Ferrucci; John R B Perry; Amy Matteini; Markus Perola; Toshiko Tanaka; Kaisa Silander; Neil Rice; David Melzer; Anna Murray; Christie Cluett; Linda P Fried; Demetrius Albanes; Anna-Maria Corsi; Antonio Cherubini; Jack Guralnik; Stefania Bandinelli; Andrew Singleton; Jarmo Virtamo; Jeremy Walston; Richard D Semba; Timothy M Frayling Journal: Am J Hum Genet Date: 2009-01-29 Impact factor: 11.025