| Literature DB >> 17388631 |
Mikael I Naumov1, Sergey A Sutirin, Andrey S Shavyrin, Olga G Ganina, Irina P Beletskaya, Véronique Bourgarel-Rey, Sébastien Combes, Jean-Pierre Finet, Alexey Yu Fedorov.
Abstract
2-(methoxymethoxymethyl)aryllead triacetates, obtained in situ from the corresponding arylboronic acids, reacted with 4-hydroxycoumarins, leading to 3-(2-methoxymethoxymethyl)aryl-4-hydroxycoumarin derivatives in good to high yields. These compounds underwent a cascade sequence of reactions, deprotection-halogenation-annulation, to afford polyoxygenated tetracyclic 6H,11H-[2]benzopyrano-[4,3-c] [1]benzopyran-11-ones in good yields. Some compounds showed a moderate cytotoxicity against human epithelial mammary HBL100 cells.Entities:
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Year: 2007 PMID： 17388631 DOI： 10.1021/jo062592v
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354