Ciprofloxacin penetration into the pulmonary parenchyma in Japanese patients.

PURPOSE: To assess the degree of penetration of intravenous (i.v.) ciprofloxacin into the lung parenchyma resected for lung carcinoma in Japanese patients.
METHODS: Ciprofloxacin was given i.v. over 1 h to ten Japanese patients with non-small cell lung carcinoma. We took 1 g of normal lung parenchyma and 1 ml of blood serum for analysis when the lung was resected. Ciprofloxacin concentrations were determined by high-performance liquid chromatography.
RESULTS: The mean time from the end of ciprofloxacin administration to lung resection was 135 +/- 55 min (range, 75-223 min). The mean concentrations of ciprofloxacin in the lung parenchyma and blood serum were 4.9 +/- 2.0 microg/g (range, 2.1-7.9) and 1.5 +/- 0.7 microg/ml (range, 0.8-2.7). The mean tissue per serum concentration ratio was 3.6 +/- 2.2 (range, 1.9-8.7).
CONCLUSION: The concentrations of ciprofloxacin in the lung parenchyma after i.v. administration in Japanese patients were above the minimal inhibitory concentration for bacteria from at least 75 min until 4 h later.