| Literature DB >> 17387307 |
C C van Bavel1, J van der Vlag, J H Berden.
Abstract
The binding of anti-double-stranded DNA (anti-dsDNA) autoantibodies to the glomerular basement membrane (GBM) in lupus nephritis can be explained by two mechanisms: (1) direct crossreactive binding to intrinsic glomerular antigens; (2) nucleosome-mediated binding to heparan sulfate in the GBM. Kalaaji et al. demonstrated using novel techniques that glomerular in vivo-bound antoantibodies bind to nucleosomes/dsDNA derived from apoptotic cells and not to intrinsic glomerular structures.Entities:
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Year: 2007 PMID： 17387307 DOI： 10.1038/sj.ki.5002126
Source DB: PubMed Journal: Kidney Int ISSN： 0085-2538 Impact factor: 10.612