J Fan1, X J Wang, G N Jiang, L Wang, X W Zu, X Zhou, W Gao, J A Ding. 1. Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, 507 Zheng Min Rd, Yangpu District, Shanghai 200433, PR China.
Abstract
AIM: To compare survival and outcomes of pulmonary resection for elderly NSCLC patients with that of younger controls in China. METHODS: A database which included 4792 NSCLC patients who received complete surgery from 1985 to 2005 was used. The elderly patients (>or=70) were matched 1:1 to controls (<70) by 5 variables: gender; stage; histology; pulmonary resection types; adjuvant chemotherapy. The long-term survival rates, the operative mortality and short-term death after surgery were compared. RESULTS: There were 1304 patients: 652 cases were >or=70. The 5-year OS of elderly was 39%; that of the controls was 45% (p=0.06). Operative mortality rate between elderly and the controls was similar (9/652 vs 4/652 p=0.16) but the short-term death within 2 months after the surgeries were different (23/652 vs 7/652 p=0.003). The elderly with lobectomy had a worse 5-year OS than controls (42% vs 46% p=0.05), but the 5-year OS was similar for patients who received pneumonectomy (24% vs 36% p=0.40) and the limited resections (46% vs 39% p=0.27). The 5-year OS in patients who received adjuvant chemotherapy were similar (49% vs 44% p=0.10). CONCLUSION: Elderly have the similar long-term OS with the controls. They should not be denied the curative surgery and adjuvant chemotherapy based on their chronologic age. However, elderly patients had a higher risk of short-term death after the surgery, which suggests that elderly be given more intensive care after the surgery.
AIM: To compare survival and outcomes of pulmonary resection for elderly NSCLCpatients with that of younger controls in China. METHODS: A database which included 4792 NSCLCpatients who received complete surgery from 1985 to 2005 was used. The elderly patients (>or=70) were matched 1:1 to controls (<70) by 5 variables: gender; stage; histology; pulmonary resection types; adjuvant chemotherapy. The long-term survival rates, the operative mortality and short-term death after surgery were compared. RESULTS: There were 1304 patients: 652 cases were >or=70. The 5-year OS of elderly was 39%; that of the controls was 45% (p=0.06). Operative mortality rate between elderly and the controls was similar (9/652 vs 4/652 p=0.16) but the short-term death within 2 months after the surgeries were different (23/652 vs 7/652 p=0.003). The elderly with lobectomy had a worse 5-year OS than controls (42% vs 46% p=0.05), but the 5-year OS was similar for patients who received pneumonectomy (24% vs 36% p=0.40) and the limited resections (46% vs 39% p=0.27). The 5-year OS in patients who received adjuvant chemotherapy were similar (49% vs 44% p=0.10). CONCLUSION: Elderly have the similar long-term OS with the controls. They should not be denied the curative surgery and adjuvant chemotherapy based on their chronologic age. However, elderly patients had a higher risk of short-term death after the surgery, which suggests that elderly be given more intensive care after the surgery.
Authors: Chi-Fu Jeffrey Yang; Nicholas R Mayne; Hanghang Wang; Ryan R Meyerhoff; Sameer Hirji; Betty C Tong; Matthew Hartwig; David Harpole; Thomas A D'Amico; Mark Berry Journal: Ann Thorac Surg Date: 2016-05-25 Impact factor: 4.330
Authors: Paul J Speicher; Asvin M Ganapathi; Brian R Englum; Mark W Onaitis; Thomas A D'Amico; Mark F Berry Journal: J Am Coll Surg Date: 2013-12-12 Impact factor: 6.113
Authors: J Guo; D Kim; J Gao; C Kurtyka; H Chen; C Yu; D Wu; A Mittal; A A Beg; S P Chellappan; E B Haura; J Q Cheng Journal: Oncogene Date: 2012-02-13 Impact factor: 9.867