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Literature DB >> 17386258

PHLPPing it off: phosphatases get in the Akt.

Abstract

Three Akt isoforms differentially control cell survival, growth, proliferation, metabolism, and motility. In this issue of Molecular Cell, Brognard et al. (2007) report that two PHLPP phosphatases specifically downregulate the Akts to control the activity of isoform-specific substrates.

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Year: 2007 PMID： 17386258 DOI： 10.1016/j.molcel.2007.03.007

Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970

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Cited

18 in total

1. Inactivation of host Akt/protein kinase B signaling by bacterial pore-forming toxins.

Authors: Travis J Wiles; Bijaya K Dhakal; Danelle S Eto; Matthew A Mulvey
Journal: Mol Biol Cell Date: 2008-01-30 Impact factor: 4.138

2. Depletion of Pleckstrin homology domain leucine-rich repeat protein phosphatases 1 and 2 by Bcr-Abl promotes chronic myelogenous leukemia cell proliferation through continuous phosphorylation of Akt isoforms.

Authors: Isao Hirano; Satoki Nakamura; Daisuke Yokota; Takaaki Ono; Kazuyuki Shigeno; Shinya Fujisawa; Kaori Shinjo; Kazunori Ohnishi
Journal: J Biol Chem Date: 2009-03-04 Impact factor: 5.157

3. USP1 regulates AKT phosphorylation by modulating the stability of PHLPP1 in lung cancer cells.

Authors: Zhang Zhiqiang; Yang Qinghui; Zhang Yongqiang; Zhang Jian; Zhao Xin; Ma Haiying; Guo Yuepeng
Journal: J Cancer Res Clin Oncol Date: 2012-03-20 Impact factor: 4.553

4. Exploitation of the ability of γ-tocopherol to facilitate membrane co-localization of Akt and PHLPP1 to develop PHLPP1-targeted Akt inhibitors.

Authors: Ribai Yan; Hsiao-Ching Chuang; Naval Kapuriya; Chih-Chien Chou; Po-Ting Lai; Hsin-Wen Chang; Chia-Ning Yang; Samuel K Kulp; Ching-Shih Chen
Journal: J Med Chem Date: 2015-02-27 Impact factor: 7.446

5. RasGAP Shields Akt from Deactivating Phosphatases in Fibroblast Growth Factor Signaling but Loses This Ability Once Cleaved by Caspase-3.

Authors: Katia Cailliau; Arlette Lescuyer; Anne-Françoise Burnol; Álvaro Cuesta-Marbán; Christian Widmann; Edith Browaeys-Poly
Journal: J Biol Chem Date: 2015-06-24 Impact factor: 5.157

PHLPPing it off: phosphatases get in the Akt.

1. Inactivation of host Akt/protein kinase B signaling by bacterial pore-forming toxins.

2. Depletion of Pleckstrin homology domain leucine-rich repeat protein phosphatases 1 and 2 by Bcr-Abl promotes chronic myelogenous leukemia cell proliferation through continuous phosphorylation of Akt isoforms.

3. USP1 regulates AKT phosphorylation by modulating the stability of PHLPP1 in lung cancer cells.

4. Exploitation of the ability of γ-tocopherol to facilitate membrane co-localization of Akt and PHLPP1 to develop PHLPP1-targeted Akt inhibitors.

5. RasGAP Shields Akt from Deactivating Phosphatases in Fibroblast Growth Factor Signaling but Loses This Ability Once Cleaved by Caspase-3.

6. Physiological regulation of Akt activity and stability.

Review 7. Regulation of Akt signaling activation by ubiquitination.

8. SGT1 regulates Akt signaling by promoting beta-TrCP-dependent PHLPP1 degradation in gastric cancer cells.

9. Defining the human deubiquitinating enzyme interaction landscape.

10. Common polymorphism in the phosphatase PHLPP2 results in reduced regulation of Akt and protein kinase C.