Literature DB >> 17386256

Mdm2: p53's lifesaver?

Ayelet Shmueli1, Moshe Oren.   

Abstract

In a recent issue of Molecular Cell, Taira et al. (2007) and Rinaldo et al. (2007) provide insight into the involvement of the DYRK2 kinase and a surprising role of MDM2 in regulation of DNA damage-induced apoptosis via p53 phosphorylation.

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Year:  2007        PMID： 17386256     DOI： 10.1016/j.molcel.2007.03.006

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  12 in total

1.  Mdm2 promotes Cdc25C protein degradation and delays cell cycle progression through the G2/M phase.

Authors:  L E Giono; L Resnick-Silverman; L A Carvajal; S St Clair; J J Manfredi
Journal:  Oncogene       Date:  2017-08-14       Impact factor: 9.867

2.  In Vivo Evaluation of Combined CK2 Inhibition and Irradiation in Human WiDr Tumours.

Authors:  Felix Zwicker; Henrik Hauswald; Klaus-Josef Weber; JÜrgen Debus; Peter E Huber
Journal:  In Vivo       Date:  2021 Jan-Feb       Impact factor: 2.155

3.  Carcinogen-induced hepatic tumors in KLF6+/- mice recapitulate aggressive human hepatocellular carcinoma associated with p53 pathway deregulation.

Authors:  Mirko Tarocchi; Rebekka Hannivoort; Yujin Hoshida; Ursula E Lee; Diana Vetter; Goutham Narla; Augusto Villanueva; Moshe Oren; Josep M Llovet; Scott L Friedman
Journal:  Hepatology       Date:  2011-06-26       Impact factor: 17.425

Review 4.  MDM4 alternative splicing and implication in MDM4 targeted cancer therapies.

Authors:  Jin Wu; Guanting Lu; Xinjiang Wang
Journal:  Am J Cancer Res       Date:  2021-12-15       Impact factor: 6.166

5.  HIPK2 is involved in cell proliferation and its suppression promotes growth arrest independently of DNA damage.

Authors:  S Iacovelli; L Ciuffini; C Lazzari; G Bracaglia; C Rinaldo; A Prodosmo; A Bartolazzi; A Sacchi; S Soddu
Journal:  Cell Prolif       Date:  2009-03-31       Impact factor: 6.831

6.  MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway.

Authors:  Francesca Mancini; Giusy Di Conza; Marsha Pellegrino; Cinzia Rinaldo; Andrea Prodosmo; Simona Giglio; Igea D'Agnano; Fulvio Florenzano; Lara Felicioni; Fiamma Buttitta; Antonio Marchetti; Ada Sacchi; Alfredo Pontecorvi; Silvia Soddu; Fabiola Moretti
Journal:  EMBO J       Date:  2009-06-11       Impact factor: 11.598

7.  A specific inhibitor of protein kinase CK2 delays gamma-H2Ax foci removal and reduces clonogenic survival of irradiated mammalian cells.

Authors:  Felix Zwicker; Maren Ebert; Peter E Huber; Jürgen Debus; Klaus-Josef Weber
Journal:  Radiat Oncol       Date:  2011-02-10       Impact factor: 3.481

8.  Role of p53 serine 46 in p53 target gene regulation.

Authors:  Leonie Smeenk; Simon J van Heeringen; Max Koeppel; Bianca Gilbert; Eva Janssen-Megens; Hendrik G Stunnenberg; Marion Lohrum
Journal:  PLoS One       Date:  2011-03-04       Impact factor: 3.240

9.  miR-24-2 controls H2AFX expression regardless of gene copy number alteration and induces apoptosis by targeting antiapoptotic gene BCL-2: a potential for therapeutic intervention.

Authors:  Niloo Srivastava; Siddharth Manvati; Archita Srivastava; Ranjana Pal; Ponnusamy Kalaiarasan; Shilpi Chattopadhyay; Sailesh Gochhait; Raina Dua; Rameshwar N K Bamezai
Journal:  Breast Cancer Res       Date:  2011-04-04       Impact factor: 6.466

10.  MDM4 (MDMX) and its Transcript Variants.

Authors:  F Mancini; G Di Conza; F Moretti
Journal:  Curr Genomics       Date:  2009-03       Impact factor: 2.236
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