| Literature DB >> 17384985 |
Ryuhei Kitai1, Kazuyo Ishisaka, Kazufumi Sato, Takahiro Sakuma, Takahiro Yamauchi, Yoshiaki Imamura, Hideki Matsumoto, Toshihiko Kubota.
Abstract
The majority of primary central nervous system lymphomas (PCNSL) are diffuse large B-cell lymphomas. Histologically, reactive T lymphocytes and mono-histiocytic cells are found within PCNSL tissue. To clarify the mechanisms of the cellular infiltration, the presence of monocyte chemoattractant protein (MCP-1) was investigated in biopsy samples of 19 cases of PCNSL by means of immunohistochemical staining, double staining with a confocal laser microscope, and Western blot analysis. MCP-1 expression was observed in all PCNSL immunohistochemically. Western blot analysis showed that the concentration of MCP-1 in PCNSL was as high as that in a metastatic brain tumor. In normal brain tissue, MCP-1 was not detected. Confocal laser microscope revealed MCP-1 signals were present in the cells with CD20, a B-cell marker. We concluded that lymphoma cells produced MCP-1, which is an additional cytokine involved in the pathogenesis of PCNSL.Entities:
Mesh：
Substances：
Year: 2007 PMID： 17384985 DOI： 10.1007/s00795-006-0350-7
Source DB: PubMed Journal: Med Mol Morphol ISSN： 1860-1499 Impact factor: 2.309