| Literature DB >> 17383899 |
Debasish Banerjee1, Balazs Hegedus, David H Gutmann, Joel R Garbow.
Abstract
One of the major limitations to preclinical mouse therapeutic evaluation is the inherent difficulty in imaging small tumors in vivo. We present a rapid and reliable method to detect optic glioma (OPG) in a mouse neurofibromatosis-1 model (Nf1(flox/mut)GFAP-Cre mice) in vivo using Manganese-Enhanced Magnetic Resonance Imaging (MEMRI). In a blinded study, 23 mice were chosen randomly from a cohort of Nf1(flox/mut)GFAP-Cre mice and two sets of age-matched controls. In all cases, OPG presence or absence was correctly identified. In addition, the OPG size and shape were accurately measured in vivo, facilitating the use of this model for preclinical drug studies.Entities:
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Year: 2007 PMID： 17383899 PMCID： PMC2735870 DOI： 10.1016/j.neuroimage.2007.02.019
Source DB: PubMed Journal: Neuroimage ISSN： 1053-8119 Impact factor: 6.556