| Literature DB >> 17383874 |
James J Li1, Haixia Wang, Joseph A Tino, Jeffrey A Robl, Timothy F Herpin, R Michael Lawrence, Scott Biller, Haris Jamil, Randy Ponticiello, Luping Chen, Ching-hsuen Chu, Neil Flynn, Dong Cheng, Rulin Zhao, Bangchi Chen, Dora Schnur, Mary T Obermeier, Vito Sasseville, Ramesh Padmanabha, Kristen Pike, Thomas Harrity.
Abstract
A novel series of 2-hydroxy-N-arylbenzenesulfonamides were identified to be ATP-citrate lyase (ACL) inhibitors with compound 9 displaying potent in vitro activity (IC(50)=0.13 microM). Chronic oral dosing of compound 9 in high-fat fed mice lowered plasma cholesterol, triglyceride, and glucose, as well as inhibited weight gain.Entities:
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Year: 2007 PMID： 17383874 DOI： 10.1016/j.bmcl.2007.03.017
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823