Literature DB >> 17383635

Pharmacokinetic profile of cocaine following intravenous administration in the female rabbit.

Joshua P Parlaman1, Barbara L Thompson, Pat Levitt, Gregg D Stanwood.   

Abstract

Prenatal cocaine exposure in a rabbit intravenous model has revealed selective disruption of brain development and pharmacological responsiveness. We therefore examined the pharmacokinetic properties of cocaine in this model. Dutch-belted rabbits were surgically implanted with a catheter in the carotid artery, allowed to recover, and then injected intravenously with a cocaine bolus. Cocaine and benzoylecgonine concentrations were measured in arterial blood plasma and analyzed by nonlinear regression and noncompartmental analyses. Peak cocaine concentration occurred by 30s, was transient, and distribution was rapid. The profile of cocaine in the rabbit is similar to that observed in humans using cocaine at recreational doses.

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Year:  2007        PMID： 17383635      PMCID： PMC1945095          DOI： 10.1016/j.ejphar.2007.02.035

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   5.195


  52 in total

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