Literature DB >> 17383196

mTOR at the crossroads of T cell proliferation and tolerance.

Anna Mondino1, Daniel L Mueller.   

Abstract

Several events control the activation, proliferation, and the continued Ag responsiveness of naïve and memory T lymphocytes. Here we review the individual contributions of TCR, CD28, and IL-2-driven signaling to T cell proliferation and anergy avoidance. The role of mTOR as a rheostat capable of integrating extracellular, plasma membrane-associated, and intracellular signals with relevance to T cell priming and tolerance is discussed.

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Year:  2007        PMID： 17383196      PMCID： PMC1995654          DOI： 10.1016/j.smim.2007.02.008

Source DB:  PubMed          Journal:  Semin Immunol        ISSN： 1044-5323            Impact factor:   11.130


  129 in total

1.  The immunological synapse and CD28-CD80 interactions.

Authors:  S K Bromley; A Iaboni; S J Davis; A Whitty; J M Green; A S Shaw; A Weiss; M L Dustin
Journal:  Nat Immunol       Date:  2001-12       Impact factor: 25.606

2.  Antagonistic roles for CTLA-4 and the mammalian target of rapamycin in the regulation of clonal anergy: enhanced cell cycle progression promotes recall antigen responsiveness.

Authors:  T L Vanasek; A Khoruts; T Zell; D L Mueller
Journal:  J Immunol       Date:  2001-11-15       Impact factor: 5.422

3.  Adaptive tolerance of CD4+ T cells in vivo: multiple thresholds in response to a constant level of antigen presentation.

Authors:  C Tanchot; D L Barber; L Chiodetti; R H Schwartz
Journal:  J Immunol       Date:  2001-08-15       Impact factor: 5.422

4.  Transactivation by AP-1 is a molecular target of T cell clonal anergy.

Authors:  S M Kang; B Beverly; A C Tran; K Brorson; R H Schwartz; M J Lenardo
Journal:  Science       Date:  1992-08-21       Impact factor: 47.728

Review 5.  AP-1 in cell proliferation and survival.

Authors:  E Shaulian; M Karin
Journal:  Oncogene       Date:  2001-04-30       Impact factor: 9.867

6.  Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells.

Authors:  D Tzachanis; G J Freeman; N Hirano; A A van Puijenbroek; M W Delfs; A Berezovskaya; L M Nadler; V A Boussiotis
Journal:  Nat Immunol       Date:  2001-12       Impact factor: 25.606

Review 7.  Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins.

Authors:  Lawrence E Samelson
Journal:  Annu Rev Immunol       Date:  2001-10-04       Impact factor: 28.527

8.  CD28 signaling augments Elk-1-dependent transcription at the c-fos gene during antigen stimulation.

Authors:  W Li; C D Whaley; J L Bonnevier; A Mondino; M E Martin; K M Aagaard-Tillery; D L Mueller
Journal:  J Immunol       Date:  2001-07-15       Impact factor: 5.422

9.  The tor pathway regulates gene expression by linking nutrient sensing to histone acetylation.

Authors:  John R Rohde; Maria E Cardenas
Journal:  Mol Cell Biol       Date:  2003-01       Impact factor: 4.272

10.  Anergy in peripheral memory CD4(+) T cells induced by low avidity engagement of T cell receptor.

Authors:  S Mirshahidi; C T Huang; S Sadegh-Nasseri
Journal:  J Exp Med       Date:  2001-09-17       Impact factor: 14.307
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  46 in total

Review 1.  The role of mTOR in memory CD8 T-cell differentiation.

Authors:  Koichi Araki; Ben Youngblood; Rafi Ahmed
Journal:  Immunol Rev       Date:  2010-05       Impact factor: 12.988

Review 2.  Immune dysfunction in autism: a pathway to treatment.

Authors:  Milo Careaga; Judy Van de Water; Paul Ashwood
Journal:  Neurotherapeutics       Date:  2010-07       Impact factor: 7.620

Review 3.  Mechanisms maintaining peripheral tolerance.

Authors:  Daniel L Mueller
Journal:  Nat Immunol       Date:  2009-12-17       Impact factor: 25.606

4.  Molecular Targeting of Immunosuppressants Using a Bifunctional Elastin-Like Polypeptide.

Authors:  Yaping Ju; Hao Guo; Frances Yarber; Maria C Edman; Santosh Peddi; Srikanth Reddy Janga; J Andrew MacKay; Sarah F Hamm-Alvarez
Journal:  Bioconjug Chem       Date:  2019-08-23       Impact factor: 4.774

Review 5.  Paradoxical aspects of rapamycin immunobiology in transplantation.

Authors:  I R Ferrer; K Araki; M L Ford
Journal:  Am J Transplant       Date:  2011-04       Impact factor: 8.086

Review 6.  The obesity-related pathology and Th17 cells.

Authors:  Yusuke Endo; Koutaro Yokote; Toshinori Nakayama
Journal:  Cell Mol Life Sci       Date:  2016-10-18       Impact factor: 9.261

7.  IL-2 signaling prevents T cell anergy by inhibiting the expression of anergy-inducing genes.

Authors:  Myrianne Duré; Fernando Macian
Journal:  Mol Immunol       Date:  2008-11-05       Impact factor: 4.407

8.  IL-1beta-driven ST2L expression promotes maturation resistance in rapamycin-conditioned dendritic cells.

Authors:  Heth R Turnquist; Tina L Sumpter; Allan Tsung; Alan F Zahorchak; Atsunori Nakao; Gerard J Nau; Foo Y Liew; David A Geller; Angus W Thomson
Journal:  J Immunol       Date:  2008-07-01       Impact factor: 5.422

9.  IL-2 as a therapeutic target for the restoration of Foxp3+ regulatory T cell function in organ-specific autoimmunity: implications in pathophysiology and translation to human disease.

Authors:  Eva d'Hennezel; Mara Kornete; Ciriaco A Piccirillo
Journal:  J Transl Med       Date:  2010-11-08       Impact factor: 5.531

10.  CD98hc facilitates B cell proliferation and adaptive humoral immunity.

Authors:  Joseph Cantor; Cecille D Browne; Raphael Ruppert; Chloé C Féral; Reinhard Fässler; Robert C Rickert; Mark H Ginsberg
Journal:  Nat Immunol       Date:  2009-03-08       Impact factor: 25.606
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