| Literature DB >> 17382877 |
Abstract
Platelets are cell fragments lacking nuclei that play a key role in blood clotting. Using an impressive genetic screen involving ENU-mutagenesis of whole mice, Mason et al. (2007) report in this issue their identification of mutations in the antiapoptotic protein Bcl-x(L) that cause accelerated death of platelets leading to platelet deficiency.Entities:
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Year: 2007 PMID： 17382877 DOI： 10.1016/j.cell.2007.03.002
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582