OBJECTIVES: To report our experience with renal cell carcinoma in patients with end-stage renal failure receiving dialysis at two institutions that perform a large number of transplantations. Renal cell carcinoma is more frequent in patients with end-stage renal failure treated with dialysis and in renal transplant patients than in the population at large. METHODS: We reviewed the case histories of 1375 consecutive patients who had transplanted kidneys functioning for more than 1 year. RESULTS: Eleven renal tumors were found in 10 patients (1.37%); 10 of the tumors (90%) were in the native kidney (9 unilateral and 1 bilateral) and 1 (10%) was in the transplanted kidney. The tumors in the native kidneys were discovered incidentally. Three were in organs removed for treatment of arterial hypertension and the other seven were found by ultrasonography. The tumor in the transplanted kidney was found after nephrectomy for the treatment of hematuria. The tumor types were clear cell in six, papillary in four, and chromophobe in one. Of the 9 patients who were treated with radical nephrectomy, 7 were alive with no evidence of the disease and 2 had died of other causes, also with no evidence of the disease. One patient who already had metastases at the diagnosis did not undergo surgery and died 4 months later. CONCLUSIONS: The native kidneys of renal transplant patients should be examined by ultrasonography annually because they are at greater risk of renal cell carcinoma. Radical nephrectomy cures those cases in which the tumors are clinically localized and 6 cm or less in size.
OBJECTIVES: To report our experience with renal cell carcinoma in patients with end-stage renal failure receiving dialysis at two institutions that perform a large number of transplantations. Renal cell carcinoma is more frequent in patients with end-stage renal failure treated with dialysis and in renal transplant patients than in the population at large. METHODS: We reviewed the case histories of 1375 consecutive patients who had transplanted kidneys functioning for more than 1 year. RESULTS: Eleven renal tumors were found in 10 patients (1.37%); 10 of the tumors (90%) were in the native kidney (9 unilateral and 1 bilateral) and 1 (10%) was in the transplanted kidney. The tumors in the native kidneys were discovered incidentally. Three were in organs removed for treatment of arterial hypertension and the other seven were found by ultrasonography. The tumor in the transplanted kidney was found after nephrectomy for the treatment of hematuria. The tumor types were clear cell in six, papillary in four, and chromophobe in one. Of the 9 patients who were treated with radical nephrectomy, 7 were alive with no evidence of the disease and 2 had died of other causes, also with no evidence of the disease. One patient who already had metastases at the diagnosis did not undergo surgery and died 4 months later. CONCLUSIONS: The native kidneys of renal transplantpatients should be examined by ultrasonography annually because they are at greater risk of renal cell carcinoma. Radical nephrectomy cures those cases in which the tumors are clinically localized and 6 cm or less in size.
Authors: Alberto Breda; Giuseppe Lucarelli; Giuseppe Luccarelli; Oscar Rodriguez-Faba; Luis Guirado; Carmen Facundo; Carlo Bettocchi; Loreto Gesualdo; Giuseppe Castellano; Giuseppe Grandaliano; Michele Battaglia; Juan Palou; Pasquale Ditonno; Humberto Villavicencio Journal: World J Urol Date: 2014-02-07 Impact factor: 4.226
Authors: Fernando Vázquez Alonso; Enrique Cardozo Rodríguez; Ignacio Puche Sanz; Jose Francisco Flores Martin; Jose Miguel Molina Hernandez; Raquel Berrio Campos; Javier Vicente Prados; Antonio Medina Benitez; Jose Manuel Cózar Olmo Journal: Case Rep Urol Date: 2012-07-17
Authors: Ian Zheng; Mahmoud Alameddine; Yaohong Tan; Zhobin Moghadamyeghaneh; Joshua S Jue; Ali Yusufali; Ahmed Farag; Gaetano Ciancio Journal: Case Rep Transplant Date: 2017-09-14