Diana Swolin-Eide1, Per Magnusson, Sverker Hansson. 1. Department of Pediatrics, Institute for Clinical Sciences, The Queen Silvia Children's Hospital, The Sahlgrenska Academy at Göteborg University, SE-416 85 Göteborg, Sweden. diana.swolin-eide@vgregion.se
Abstract
AIM: This study was designed to investigate bone mineral density (BMD), growth parameters and biochemical markers in children with chronic kidney disease (CKD). METHODS: Sixteen patients, 4-18 years, with CKD were prospectively followed for 1 year. Auxological data, body composition, BMD by dual-energy X-ray absorptiometry, bone age, bone turnover markers, vitamin D, parathyroid hormone (PTH), leptin, osteoprotegerin, insulin-like growth factor-I (IGF-I) and IGF binding protein-3 were measured. A questionnaire regarding bone health and diet was also performed. RESULTS: Delayed bone age was observed (n = 11) and the BMD Z-scores for total body were below zero in seven patients. However, total body BMD (TBBMD) increased in 12 patients. Most patients had increased osteocalcin and carboxy-terminal telopeptide of type I collagen, but normal alkaline phosphatase, type I procollagen intact amino-terminal propeptide and tartrate-resistant acid phosphatase 5b. Ten patients had increased PTH. Most children had normal levels of leptin, osteoprotegerin, IGF-I and IGFBP-3. Leptin, at baseline, correlated with differences in TBBMD over 1 year. CONCLUSIONS: Only seven (44%) had negative Z-scores and TBBMD increased over 1 year. Bone markers at baseline did not predict the longitudinal changes in BMD.
AIM: This study was designed to investigate bone mineral density (BMD), growth parameters and biochemical markers in children with chronic kidney disease (CKD). METHODS: Sixteen patients, 4-18 years, with CKD were prospectively followed for 1 year. Auxological data, body composition, BMD by dual-energy X-ray absorptiometry, bone age, bone turnover markers, vitamin D, parathyroid hormone (PTH), leptin, osteoprotegerin, insulin-like growth factor-I (IGF-I) and IGF binding protein-3 were measured. A questionnaire regarding bone health and diet was also performed. RESULTS: Delayed bone age was observed (n = 11) and the BMD Z-scores for total body were below zero in seven patients. However, total body BMD (TBBMD) increased in 12 patients. Most patients had increased osteocalcin and carboxy-terminal telopeptide of type I collagen, but normal alkaline phosphatase, type I procollagen intact amino-terminal propeptide and tartrate-resistant acid phosphatase 5b. Ten patients had increased PTH. Most children had normal levels of leptin, osteoprotegerin, IGF-I and IGFBP-3. Leptin, at baseline, correlated with differences in TBBMD over 1 year. CONCLUSIONS: Only seven (44%) had negative Z-scores and TBBMD increased over 1 year. Bone markers at baseline did not predict the longitudinal changes in BMD.
Authors: Rachel J Wetzsteon; Heidi J Kalkwarf; Justine Shults; Babette S Zemel; Bethany J Foster; Lindsay Griffin; C Frederic Strife; Debbie L Foerster; Darlene K Jean-Pierre; Mary B Leonard Journal: J Bone Miner Res Date: 2011-09 Impact factor: 6.741
Authors: Lindsay M Griffin; Heidi J Kalkwarf; Babette S Zemel; Justine Shults; Rachel J Wetzsteon; C Frederic Strife; Mary B Leonard Journal: Pediatr Nephrol Date: 2012-02-16 Impact factor: 3.714
Authors: Anne Tsampalieros; Heidi J Kalkwarf; Rachel J Wetzsteon; Justine Shults; Babette S Zemel; Bethany J Foster; Debbie L Foerster; Mary B Leonard Journal: Kidney Int Date: 2012-10-03 Impact factor: 10.612