Literature DB >> 17379527

Alpha-phenyl-N-tert-butyl nitrone (PBN) derivatives: synthesis and protective action against microvascular damages induced by ischemia/reperfusion.

Sothea Kim1, Guilherme V M de A Vilela, Jalloul Bouajila, Ayres G Dias, Fatima Z G A Cyrino, Eliete Bouskela, Paulo R R Costa, Françoise Nepveu.   

Abstract

Nitrones 4-7, structurally related to PBN (1), were prepared by reaction of the corresponding aromatic aldehydes with N-tert-butyl hydroxylamine. The protective effects of these nitrones against microvascular damages in ischemia/reperfusion in the 'hamster cheek pouch' assay were studied and 1, as well as 4a, 4b, and 7 (derived from piperonal, O-benzyl vanillin, and furfural, respectively), showed to be more active than shark cartilage or alpha-tocopherol. No correlation was found between the protective effect of these nitrones and their logP (partition coefficient) or their capacity to trap (*)OH and (*)CH(3) radicals.

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Year:  2007        PMID： 17379527     DOI： 10.1016/j.bmc.2007.02.033

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  7 in total

1.  Pharmacokinetic study of a novel stroke therapeutic, 2-[[(1,1-dimethylethyl)oxidoimino]methyl]-3,5,6-trimethylpyrazine, by a simple HPLC-UV method in rats.

Authors:  Sha Li; Hainan Chen; Xingli Wang; Jianfeng Wu; Jie Jiang; Yuqiang Wang
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2011-03-22       Impact factor: 2.441

2.  Studies into radiolytic decomposition of fluorine-18 labeled radiopharmaceuticals for positron emission tomography.

Authors:  Peter J H Scott; Brian G Hockley; Hank F Kung; Rajesh Manchanda; Wei Zhang; Michael R Kilbourn
Journal:  Appl Radiat Isot       Date:  2008-09-07       Impact factor: 1.513

3.  Tumor necrosis factor-alpha and apoptosis signal-regulating kinase 1 control reactive oxygen species release, mitochondrial autophagy, and c-Jun N-terminal kinase/p38 phosphorylation during necrotizing enterocolitis.

Authors:  Naira Baregamian; Jun Song; C Eric Bailey; John Papaconstantinou; B Mark Evers; Dai H Chung
Journal:  Oxid Med Cell Longev       Date:  2009 Nov-Dec       Impact factor: 6.543

4.  Inhibition of ROS-induced apoptosis in endothelial cells by nitrone spin traps via induction of phase II enzymes and suppression of mitochondria-dependent pro-apoptotic signaling.

Authors:  Amlan Das; Bhavani Gopalakrishnan; Oliver H Voss; Andrea I Doseff; Frederick A Villamena
Journal:  Biochem Pharmacol       Date:  2012-05-10       Impact factor: 5.858

5.  Mutagenic and Cytotoxicity LQB 123 Profile: Safety and Tripanocidal Effect of a Phenyl-t-Butylnitrone Derivative.

Authors:  Mauricio Peixoto Cupello; Francis Monique Saraiva; Pedro Ippolito; Andréia da Silva Fernandes; Rubem Figueiredo Sadoko Menna-Barreto; Debora de Sousa Dos Santos Costa; Jessica Isis Oliveira Paula; Paulo Roberto Ribeiro Costa; Natália Pereira Nogueira; Israel Felzenswalb; Ayres Guimarães Dias; Marcia Cristina Paes
Journal:  Biomed Res Int       Date:  2017-02-15       Impact factor: 3.411

6.  Para-Substituted α-Phenyl-N-tert-butyl Nitrones: Spin-Trapping, Redox and Neuroprotective Properties.

Authors:  Anaïs Deletraz; Béatrice Tuccio; Julien Roussel; Maud Combes; Catherine Cohen-Solal; Paul-Louis Fabre; Patrick Trouillas; Michel Vignes; Noelle Callizot; Grégory Durand
Journal:  ACS Omega       Date:  2020-11-20

7.  Synthesis of N-arylpyridinium salts bearing a nitrone spin trap as potential mitochondria-targeted antioxidants.

Authors:  Linsey Robertson; Richard C Hartley
Journal:  Tetrahedron       Date:  2009-07-04       Impact factor: 2.457
  7 in total

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