| Literature DB >> 17379399 |
Crystal Sao-Fong Cheung1, Karen Ka-Wing Chung, Julian Chun-Kin Lui, Ching-Po Lau, Po-Ming Hon, Judy Yuet-Wa Chan, Kwok-Pui Fung, Shannon Wing-Ngor Au.
Abstract
The Chinese herbal medicine Radix Sophorae is widely applied as an anti-carcinogenic/ anti-metastatic agent against liver cancer. In this study, Leachianone A, isolated from Radix Sophorae, possessed a profound cytotoxic activity against human hepatoma cell line HepG2 in vitro, with an IC(50) value of 3.4microg/ml post-48-h treatment. Its action mechanism via induction of apoptosis involved both extrinsic and intrinsic pathways. Its anti-tumor effect was further demonstrated in vivo by 17-54% reduction of tumor size in HepG2-bearing nude mice, in which no toxicity to the heart and liver tissues was observed. In conclusion, this is the first report describing the isolation of Leachianone A from Radix Sophorae and the molecular mechanism of its anti-proliferative effect on HepG2 cells.Entities:
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Year: 2007 PMID： 17379399 DOI： 10.1016/j.canlet.2007.01.025
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679