| Literature DB >> 17379377 |
Takashi Fujita1, Kazuhide Onoguchi, Koji Onomoto, Reiko Hirai, Mitsutoshi Yoneyama.
Abstract
TLRs detect several classes of virus-associated molecules, such as ssRNA, CpG-DNA and dsRNA, and transduce signals leading to the production of IFN. Recently discovered cytoplasmic RNA helicases, RIG-I and MDA5, selectively sense viral RNA species. Gene disruption studies revealed the critical but non-redundant function of RIG-I and MDA5 in host antiviral responses.Entities:
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Year: 2007 PMID： 17379377 DOI： 10.1016/j.biochi.2007.01.013
Source DB: PubMed Journal: Biochimie ISSN： 0300-9084 Impact factor: 4.079