| Literature DB >> 17379212 |
George Dautu1, Biscah Munyaka, Gabriella Carmen, Guohong Zhang, Yoshitaka Omata, Xuan Xuenan, Makoto Igarashi.
Abstract
A combination of antigenic regions of microneme proteins have been previously reported as being protective against chronic toxoplasmosis. In this work, we evaluated immune responses induced by immunizing BALB/c and C57BL/6 mice intradermally with plasmid DNA encoding the protein sequences of Toxoplasma gondii AMA1, MIC2, M2AP and BAG1. Mice immunized with the AMA1 gene developed high levels of serum IgG2a and c antibodies as well as cellular immune responses associated with IFN-gamma synthesis suggesting a modulated Th1 type of response. Immunization with the AMA1 gene resulted in a partial but significant protection against the acute phase of toxoplasmosis compared to MIC2, M2AP and BAG1 genes. Therefore, the AMA1 gene appears to generate a strong specific immune response and also provides effective protection against toxoplasmosis more than the MIC2, M2AP and BAG1 genes.Entities:
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Year: 2007 PMID： 17379212 DOI： 10.1016/j.exppara.2007.01.017
Source DB: PubMed Journal: Exp Parasitol ISSN： 0014-4894 Impact factor: 2.011