Literature DB >> 17378545

Pyrogallol-based molecules as potent inhibitors of the antiapoptotic Bcl-2 proteins.

Guozhi Tang1, Chao-Yie Yang, Zaneta Nikolovska-Coleska, Jie Guo, Su Qiu, Renxiao Wang, Wei Gao, Guoping Wang, Jeanne Stuckey, Krzysztof Krajewski, Sheng Jiang, Peter P Roller, Shaomeng Wang.   

Abstract

We report herein a new class of small-molecule inhibitors of antiapoptotic Bcl-2 proteins. The most potent compound, 7, binds to Bcl-2, Bcl-xL, and Mcl-1 proteins with Ki of 110, 638, and 150 nM, respectively. Compound 7 is highly effective in induction of cell death in breast cancer cells with high levels of Bcl-2, Bcl-xL, and Mcl-1 proteins and represents a promising lead compound for the design of new anticancer drugs.

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Year:  2007        PMID： 17378545      PMCID： PMC2536619          DOI： 10.1021/jm061400l

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  21 in total

1.  Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL.

Authors:  A Degterev; A Lugovskoy; M Cardone; B Mulley; G Wagner; T Mitchison; J Yuan
Journal:  Nat Cell Biol       Date:  2001-02       Impact factor: 28.824

2.  Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies.

Authors:  A M Petros; D G Nettesheim; Y Wang; E T Olejniczak; R P Meadows; J Mack; K Swift; E D Matayoshi; H Zhang; C B Thompson; S W Fesik
Journal:  Protein Sci       Date:  2000-12       Impact factor: 6.725

Review 3.  From bench to clinic with apoptosis-based therapeutic agents.

Authors:  D W Nicholson
Journal:  Nature       Date:  2000-10-12       Impact factor: 49.962

Review 4.  Cancer genetics.

Authors:  B A Ponder
Journal:  Nature       Date:  2001-05-17       Impact factor: 49.962

5.  Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins.

Authors:  Shinichi Kitada; Marilisa Leone; Sina Sareth; Dayong Zhai; John C Reed; Maurizio Pellecchia
Journal:  J Med Chem       Date:  2003-09-25       Impact factor: 7.446

6.  Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak.

Authors:  Simon N Willis; Jamie I Fletcher; Thomas Kaufmann; Mark F van Delft; Lin Chen; Peter E Czabotar; Helen Ierino; Erinna F Lee; W Douglas Fairlie; Philippe Bouillet; Andreas Strasser; Ruth M Kluck; Jerry M Adams; David C S Huang
Journal:  Science       Date:  2007-02-09       Impact factor: 47.728

7.  Solution structure of the antiapoptotic protein bcl-2.

Authors:  A M Petros; A Medek; D G Nettesheim; D H Kim; H S Yoon; K Swift; E D Matayoshi; T Oltersdorf; S W Fesik
Journal:  Proc Natl Acad Sci U S A       Date:  2001-02-27       Impact factor: 11.205

Review 8.  Apoptosis in cancer.

Authors:  S W Lowe; A W Lin
Journal:  Carcinogenesis       Date:  2000-03       Impact factor: 4.944

9.  Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening.

Authors:  I J Enyedy; Y Ling; K Nacro; Y Tomita; X Wu; Y Cao; R Guo; B Li; X Zhu; Y Huang; Y Q Long; P P Roller; D Yang; S Wang
Journal:  J Med Chem       Date:  2001-12-06       Impact factor: 7.446

10.  Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3.

Authors:  S P Tzung; K M Kim; G Basañez; C D Giedt; J Simon; J Zimmerberg; K Y Zhang; D M Hockenbery
Journal:  Nat Cell Biol       Date:  2001-02       Impact factor: 28.824
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  11 in total

1.  Structure-based design of flavonoid compounds as a new class of small-molecule inhibitors of the anti-apoptotic Bcl-2 proteins.

Authors:  Guozhi Tang; Ke Ding; Zaneta Nikolovska-Coleska; Chao-Yie Yang; Su Qiu; Sanjeev Shangary; Renxiao Wang; Jie Guo; Wei Gao; Jennifer Meagher; Jeanne Stuckey; Krzysztof Krajewski; Sheng Jiang; Peter P Roller; Shaomeng Wang
Journal:  J Med Chem       Date:  2007-06-07       Impact factor: 7.446

2.  A dual-readout F2 assay that combines fluorescence resonance energy transfer and fluorescence polarization for monitoring bimolecular interactions.

Authors:  Yuhong Du; Zaneta Nikolovska-Coleska; Min Qui; Lian Li; Iestyn Lewis; Raymond Dingledine; Jeanne A Stuckey; Krzysztof Krajewski; Peter P Roller; Shaomeng Wang; Haian Fu
Journal:  Assay Drug Dev Technol       Date:  2011-03-11       Impact factor: 1.738

3.  Inhibition of protein-protein interactions with low molecular weight compounds.

Authors:  Marilyn M Matthews; David J Weber; Paul S Shapiro; Andrew Coop; Alexander D Mackerell
Journal:  Curr Trends Med Chem       Date:  2008-01-01

4.  Autophagy and Apoptosis Specific Knowledgebases-guided Systems Pharmacology Drug Research.

Authors:  Peihao Fan; Nanyi Wang; Lirong Wang
Journal:  Curr Cancer Drug Targets       Date:  2019       Impact factor: 3.428

5.  Structure-based discovery of BM-957 as a potent small-molecule inhibitor of Bcl-2 and Bcl-xL capable of achieving complete tumor regression.

Authors:  Jianfang Chen; Haibin Zhou; Angelo Aguilar; Liu Liu; Longchuan Bai; Donna McEachern; Chao-Yie Yang; Jennifer L Meagher; Jeanne A Stuckey; Shaomeng Wang
Journal:  J Med Chem       Date:  2012-10-02       Impact factor: 7.446

6.  Synthesis and evaluation of substituted hexahydronaphthalenes as novel inhibitors of the Mcl-1/BimBH3 interaction.

Authors:  Young B Kim; Maria E Balasis; Kenichiro Doi; Norbert Berndt; Courtney DuBoulay; Chih-Chi Andrew Hu; Wayne Guida; Hong-Gang Wang; Saïd M Sebti; Juan R Del Valle
Journal:  Bioorg Med Chem Lett       Date:  2012-07-24       Impact factor: 2.823

7.  sHA 14-1, a stable and ROS-free antagonist against anti-apoptotic Bcl-2 proteins, bypasses drug resistances and synergizes cancer therapies in human leukemia cell.

Authors:  Defeng Tian; Sonia G Das; Jignesh M Doshi; Jun Peng; Jialing Lin; Chengguo Xing
Journal:  Cancer Lett       Date:  2007-11-26       Impact factor: 8.679

Review 8.  Features of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinity.

Authors:  Matthew C Smith; Jason E Gestwicki
Journal:  Expert Rev Mol Med       Date:  2012-07-26       Impact factor: 5.600

9.  WL-276, an antagonist against Bcl-2 proteins, overcomes drug resistance and suppresses prostate tumor growth.

Authors:  Liangyou Wang; Daniel T Sloper; Sadiya N Addo; Defeng Tian; Joel W Slaton; Chengguo Xing
Journal:  Cancer Res       Date:  2008-06-01       Impact factor: 12.701

10.  Lignin Valorization: Two Hybrid Biochemical Routes for the Conversion of Polymeric Lignin into Value-added Chemicals.

Authors:  Weihua Wu; Tanmoy Dutta; Arul M Varman; Aymerick Eudes; Bianca Manalansan; Dominique Loqué; Seema Singh
Journal:  Sci Rep       Date:  2017-08-21       Impact factor: 4.379
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