BACKGROUND: Most drug-associated angioedemas are induced by angiotensin-converting enzyme inhibitors, angiotensin II receptor antagonists, or nonsteroidal anti-inflammatory drugs. Recently, the responsibility of immunosuppressive agents given to transplant recipients in the development of angioedema has been discussed. OBJECTIVE: To describe, in detail, angioedema episodes in renal transplant recipients (RTRs) on sirolimus. METHODS: A cross-sectional study in a university hospital. Eighty consecutive RTRs on sirolimus were studied. RESULTS: Angioedema without urticaria occurred a mean of 5 times in 12/80 (15%) RTRs taking sirolimus. It was predominantly located on the face (83%), with mucous membrane involvement in 7 (58%) patients, and was life threatening in 1. Another putative cofactor for angioedema without urticaria was identified in 9 (75%) patients: drugs (n=8), food allergy or physical activity (n=3). Tacrolimus intake was significantly associated with sirolimus-associated angioedema. CONCLUSION: Our results suggested a causal relationship between sirolimus and angioedema in RTRs. Copyright (c) 2007 S. Karger AG, Basel.
BACKGROUND: Most drug-associated angioedemas are induced by angiotensin-converting enzyme inhibitors, angiotensin II receptor antagonists, or nonsteroidal anti-inflammatory drugs. Recently, the responsibility of immunosuppressive agents given to transplant recipients in the development of angioedema has been discussed. OBJECTIVE: To describe, in detail, angioedema episodes in renal transplant recipients (RTRs) on sirolimus. METHODS: A cross-sectional study in a university hospital. Eighty consecutive RTRs on sirolimus were studied. RESULTS:Angioedema without urticaria occurred a mean of 5 times in 12/80 (15%) RTRs taking sirolimus. It was predominantly located on the face (83%), with mucous membrane involvement in 7 (58%) patients, and was life threatening in 1. Another putative cofactor for angioedema without urticaria was identified in 9 (75%) patients: drugs (n=8), food allergy or physical activity (n=3). Tacrolimus intake was significantly associated with sirolimus-associated angioedema. CONCLUSION: Our results suggested a causal relationship between sirolimus and angioedema in RTRs. Copyright (c) 2007 S. Karger AG, Basel.
Authors: J B Byrd; A Woodard-Grice; E Stone; A Lucisano; H Schaefer; C Yu; A E Eyler; N E Salloum; N J Brown Journal: Allergy Date: 2010-11 Impact factor: 13.146