Literature DB >> 17375353

Transient heart block in a neonate associated with previously undiagnosed maternal anti-Ro/SSA and anti-La/SSB antibodies.

S A Escamilla1, M D Pettersen.   

Abstract

This report presents the case of an infant who was born with transient complete heart block. The cardiac rhythm converted to normal sinus rhythm within 12 hours of life. Following the diagnosis in this infant of congenital heart block, both the mother and the infant were tested for autoantibodies. Both were found to be strongly positive for anti-Ro/SSA antibodies. The infant was also weakly positive for the anti-La/SSB antibodies and her mother moderately positive for the same. Congenital heart block associated with these maternal antibodies is well documented in the literature; however, this is the only reported case that documents a transient nature of the complete heart block.

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Year:  2007        PMID: 17375353     DOI: 10.1007/s00246-006-0015-2

Source DB:  PubMed          Journal:  Pediatr Cardiol        ISSN: 0172-0643            Impact factor:   1.655


  13 in total

1.  Increase in the heart rate-corrected QT interval in children of anti-Ro-positive mothers, with a further increase in those with siblings with congenital heart block: comment on the article by Cimaz et al.

Authors:  P A Gordon; M A Khamashta; G R Hughes; E Rosenthal
Journal:  Arthritis Rheum       Date:  2001-01

2.  Anti-SSA/Ro and anti-SSB/La autoantibodies bind the surface of apoptotic fetal cardiocytes and promote secretion of TNF-alpha by macrophages.

Authors:  M E Miranda-Carús; A D Askanase; R M Clancy; F Di Donato; T M Chou; M R Libera; E K Chan; J P Buyon
Journal:  J Immunol       Date:  2000-11-01       Impact factor: 5.422

3.  Accessibility of SSA/Ro and SSB/La antigens to maternal autoantibodies in apoptotic human fetal cardiac myocytes.

Authors:  M E Miranda; C E Tseng; W Rashbaum; R L Ochs; C A Casiano; F Di Donato; E K Chan; J P Buyon
Journal:  J Immunol       Date:  1998-11-01       Impact factor: 5.422

Review 4.  Congenital complete heart block: an international study of the natural history.

Authors:  M Michaëlsson; M A Engle
Journal:  Cardiovasc Clin       Date:  1972

Review 5.  Fetal treatment of congenital heart block ascribed to anti-SSA antibody: case reports with observation of cardiohemodynamics and review of the literature.

Authors:  H Yamada; E H Kato; Y Ebina; M Moriwaki; R Yamamoto; I Furuta; S Fujimoto
Journal:  Am J Reprod Immunol       Date:  1999-10       Impact factor: 3.886

6.  Risk of congenital complete heart block in newborns of mothers with anti-Ro/SSA antibodies detected by counterimmunoelectrophoresis: a prospective study of 100 women.

Authors:  A Brucato; M Frassi; F Franceschini; R Cimaz; D Faden; M P Pisoni; M Muscarà; G Vignati; M Stramba-Badiale; L Catelli; A Lojacono; I Cavazzana; A Ghirardello; F Vescovi; P F Gambari; A Doria; P L Meroni; A Tincani
Journal:  Arthritis Rheum       Date:  2001-08

7.  QT interval prolongation in asymptomatic anti-SSA/Ro-positive infants without congenital heart block.

Authors:  R Cimaz; M Stramba-Badiale; A Brucato; L Catelli; P Panzeri; P L Meroni
Journal:  Arthritis Rheum       Date:  2000-05

8.  Maternal anti-Ro and anti-La antibody-associated endocardial fibroelastosis.

Authors:  Lynne E Nield; Earl D Silverman; Glenn P Taylor; Jeffrey F Smallhorn; J Brendan M Mullen; Norman H Silverman; John P Finley; Yuk M Law; Derek G Human; P Gareth Seaward; Robert M Hamilton; Lisa K Hornberger
Journal:  Circulation       Date:  2002-02-19       Impact factor: 29.690

9.  Endocardial fibroelastosis associated with maternal anti-Ro and anti-La antibodies in the absence of atrioventricular block.

Authors:  Lynne E Nield; Earl D Silverman; Jeffrey F Smallhorn; Glenn P Taylor; J Brendan M Mullen; Leland N Benson; Lisa K Hornberger
Journal:  J Am Coll Cardiol       Date:  2002-08-21       Impact factor: 24.094

Review 10.  Anti-SSA/Ro antibodies and the heart: more than complete congenital heart block? A review of electrocardiographic and myocardial abnormalities and of treatment options.

Authors:  Nathalie Costedoat-Chalumeau; Zahir Amoura; Elisabeth Villain; Laurence Cohen; Jean-Charles Piette
Journal:  Arthritis Res Ther       Date:  2005-01-25       Impact factor: 5.156

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