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Literature DB >> 17375343

Confirmation of region-specific patterns of gene expression in the human brain.

Carl Ernst¹, Adolfo Sequeira, Tim Klempan, Neil Ernst, Jarlath Ffrench-Mullen, Gustavo Turecki.

Abstract

The human brain is divided and categorized in different ways, yet a molecular genetic approach to region specificity does not exist. Using data from 12 healthy control subjects across 18 brain regions, we performed a microarray analysis using both the HG-U133AB and HG-U133 plus 2 chips for each subject to determine molecular targets showing region specificity. Using a previously published data as our guide, we confirm SIX3, GPR6, SH3RF2, and hSyn as molecular markers of the nucleus accumbens and gamma-aminobutyric-acid A receptor alpha-6, Nik-related kinase, and eomesodermin as molecular markers of the cerebellum.

Entities: Chemical

Mesh：

Substances：

Year: 2007 PMID： 17375343 DOI： 10.1007/s10048-007-0084-2

Source DB: PubMed Journal: Neurogenetics ISSN： 1364-6745 Impact factor: 3.017

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