Karin Nilsson1, Lars Gustafson, Björn Hultberg. 1. Department of Psychogeriatrics, Clinical Science and Laboratory Medicine, Lund University Hospital, Lund, Sweden.
Abstract
BACKGROUND: There is an association between elevated plasma total homocysteine (tHcy) and vascular disease in elderly patients suffering from organic and non-organic mental disease. The main objective of the present study was to investigate the relationship between plasma tHcy concentration and vascular disease in elderly patients with memory complaints. METHODS: In 108 patients with memory complaints the concentration of plasma tHcy was related to the presence of vascular disease. Furthermore, different determinants of plasma tHcy concentration were measured. RESULTS: Patients with confirmed memory complaints (CMC, n = 86) which fulfilled the criteria of mild cognitive impairment were divided into two categories, with and without vascular disease. The CMC group without vascular disease showed similar biochemical and brain imaging findings to patients with subjective memory complaints (SMC, n = 22). The group of CMC patients with vascular disease had higher age, higher plasma tHcy, lower serum folate and lower renal function than patients without vascular disease. CONCLUSION: The finding of two subgroups of patients with CMC supports the notion that mild cognitive impairment is a heterogenous clinical entity with multiple aetiological factors. The elevated plasma tHcy in the group of CMC patients with vascular disease is likely to be associated with vascular disease. Copyright 2007 S. Karger AG, Basel.
BACKGROUND: There is an association between elevated plasma total homocysteine (tHcy) and vascular disease in elderly patients suffering from organic and non-organic mental disease. The main objective of the present study was to investigate the relationship between plasma tHcy concentration and vascular disease in elderly patients with memory complaints. METHODS: In 108 patients with memory complaints the concentration of plasma tHcy was related to the presence of vascular disease. Furthermore, different determinants of plasma tHcy concentration were measured. RESULTS:Patients with confirmed memory complaints (CMC, n = 86) which fulfilled the criteria of mild cognitive impairment were divided into two categories, with and without vascular disease. The CMC group without vascular disease showed similar biochemical and brain imaging findings to patients with subjective memory complaints (SMC, n = 22). The group of CMCpatients with vascular disease had higher age, higher plasma tHcy, lower serum folate and lower renal function than patients without vascular disease. CONCLUSION: The finding of two subgroups of patients with CMC supports the notion that mild cognitive impairment is a heterogenous clinical entity with multiple aetiological factors. The elevated plasma tHcy in the group of CMCpatients with vascular disease is likely to be associated with vascular disease. Copyright 2007 S. Karger AG, Basel.
Authors: Justine M Abais; Min Xia; Guangbi Li; Yang Chen; Sabena M Conley; Todd W B Gehr; Krishna M Boini; Pin-Lan Li Journal: J Biol Chem Date: 2014-08-19 Impact factor: 5.157
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