BACKGROUND: QT dispersion has been proposed to be a predictor of adverse outcomes in a variety of cardiac disease states. The objective of this study was to examine QT dispersion in patients with sickle cell disease (SCD) and to assess the effect of pulmonary hypertension (PHT) on QT dispersion. METHODS: We performed Doppler echocardiographic assessments of pulmonary artery systolic pressure in 73 (mean age 18.5 +/- 8.0 years) steady-state SCD patients and 25 (mean age 19.6 +/- 7.2 years) healthy subjects. Resting 12-lead electrocardiogram was recorded and QT dispersion was calculated as the difference between maximum and minimum QT intervals. Bazett's formula was used to obtain a rate-corrected value of the QT interval (QTc). RESULTS: Maximum QTc, minimum QTc and QTc dispersion were significantly increased in SCD patients compared to the control subjects (p < 0.0001, p < 0.05, p < 0.0001, respectively). Among SCD patients, patients with PHT had higher maximum QTc and QTc dispersion than patients without PHT (p < 0.0001). However, minimum QTc showed no significant differences between the two patient groups. CONCLUSION: QTc dispersion is significantly increased in SCD patients, especially those with PHT indicating regional inhomogeneity of ventricular repolarization. Copyright 2007 S. Karger AG, Basel.
BACKGROUND: QT dispersion has been proposed to be a predictor of adverse outcomes in a variety of cardiac disease states. The objective of this study was to examine QT dispersion in patients with sickle cell disease (SCD) and to assess the effect of pulmonary hypertension (PHT) on QT dispersion. METHODS: We performed Doppler echocardiographic assessments of pulmonary artery systolic pressure in 73 (mean age 18.5 +/- 8.0 years) steady-state SCDpatients and 25 (mean age 19.6 +/- 7.2 years) healthy subjects. Resting 12-lead electrocardiogram was recorded and QT dispersion was calculated as the difference between maximum and minimum QT intervals. Bazett's formula was used to obtain a rate-corrected value of the QT interval (QTc). RESULTS: Maximum QTc, minimum QTc and QTc dispersion were significantly increased in SCDpatients compared to the control subjects (p < 0.0001, p < 0.05, p < 0.0001, respectively). Among SCDpatients, patients with PHT had higher maximum QTc and QTc dispersion than patients without PHT (p < 0.0001). However, minimum QTc showed no significant differences between the two patient groups. CONCLUSION:QTc dispersion is significantly increased in SCDpatients, especially those with PHT indicating regional inhomogeneity of ventricular repolarization. Copyright 2007 S. Karger AG, Basel.
Authors: Zhang Hong-liang; Luo Qin; Liu Zhi-hong; Zhao Zhi-hui; Xiong Chang-ming; Ni Xin-hai; He Jian-guo; Wei Ying-jie; Zhang Shu Journal: Wien Klin Wochenschr Date: 2009 Impact factor: 1.704
Authors: Jonathan D Rich; Thenappan Thenappan; Benjamin Freed; Amit R Patel; Ronald A Thisted; Rory Childers; Stephen L Archer Journal: Int J Cardiol Date: 2012-03-27 Impact factor: 4.164
Authors: Wael N Lotfy; Nashwa M Samra; Mohamed E Al Ghwass; Sayed A Amin; Sara I AboElnour Journal: Pediatr Cardiol Date: 2016-06-10 Impact factor: 1.655