Literature DB >> 17373724

Effects of caffeine on the freezing of gait in Parkinson's disease.

Mayumi Kitagawa1, Hideki Houzen, Kunio Tashiro.   

Abstract

Caffeine is a nonselective competitive blockade of adenosine A1 and A2A receptors. In this report, we studied the efficacy of 100 mg of caffeine per day on the freezing of gait (FOG) for patients with Parkinson's disease. Different subtypes of FOG showed different therapeutic responses to caffeine. Caffeine improved "total akinesia" type of FOG, but had no effect on "trembling in place." Tolerance developed to the beneficial effect of caffeine on FOG within a few months, but a 2-week caffeine withdrawal period could restore the effect of caffeine.

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Year:  2007        PMID： 17373724     DOI： 10.1002/mds.21208

Source DB:  PubMed          Journal:  Mov Disord        ISSN： 0885-3185            Impact factor:   10.338


  12 in total

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Review 5.  Potential influences of complementary therapy on motor and non-motor complications in Parkinson's disease.

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7.  Caffeine for treatment of Parkinson disease: a randomized controlled trial.

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9.  Serum caffeine and metabolites are reliable biomarkers of early Parkinson disease.

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Journal:  Neurology       Date:  2018-01-03       Impact factor: 9.910

Review 10.  Adenosine 2A Receptor Antagonists for the Treatment of Motor Symptoms in Parkinson's Disease.

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Journal:  Mov Disord Clin Pract       Date:  2015-07-25
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