P Vanuga1, M Pura, I Plesko, M Ondrusová. 1. Endokrinologické oddelenie, Národný endokrinologický a diabetologickỳ ústav, L'ubochna, Slovensko. peter.vanuga@nedu.sk
Abstract
BACKGROUND: In this paper the authors summarise the primary malignant thyroid tumors (p.m.t.t.) incidence data from their centre over the period 1984-2005. The results are explained in the context of the p.m.t.t. incidence data from the National Cancer Register (1996 2002). METHODS AND RESULTS: Overall, 6434 thyroid operations were indicated and carried out during the sampling period at the authors' institution, of which 365 cases were histologically confirmed p.m.t.t. (5.7% of all histological findings). Specifically, p.m.t.t. were diagnosed in 295 women (80.8%) and 70 men (19.2%), with the most frequent occurrence in the 5th decade and a higher recent incidence in younger age groups. Whereas follicular thyroid carcinomas predominated in the 1984-1989 period (24 cases or 66.7%), the papillary thyroid carcinoma was the most frequent type in 1990-1997 and 1998-2005: 70 (61.4%) and 160 (74.4%) cases respectively. In the context of the national incidence, the authors' institution increasingly contributes to the diagnosis of p.m.t.t. in Slovakia (8.9% in 1996 vs. 13.9% in 2002). However, neither the progress in diagnostic methods nor the capacity expansion for patient examination can explain the increasing incidence of the p.m.t.t. (3.9/10(6) in 1996 vs. 5.6/10(6) in 2002 in women and 1.3/10(6) in 1996 vs. 1.7/10(6) in 2002 in men, respectively). CONCLUSIONS: It remains to be explained why there are significant differences in p.m.t.t. incidence among individual counties. For example, in county Trnava 0.6/10(6) in men in 1996 vs. 1.5/10(6) in 2002; in county Presov 1.2/10(6) in 1996 vs. 2.4/10(6) in 2002. Similarly, in women in county Trnava 3.6/10(6) in 1996 vs. 5.6/10(6) in 2002 and in county Presov 5.4/10(6) in 1996 vs. 8.4/10(6) in 2002. As far as the districts of Slovakia are concerned, data relative to the male population in 2002 indicate zero incidence in 42 out of 79 districts, with the highest incidence (15.9/10(6)) recorded in Svidnik. Likewise, data relative to the female population in 2002 indicate zero incidence in 15 out of 79 districts, with the highest incidence (26.5/10(6)) in Stropkov. These differences call for further (radio)epidemiological, geographical and genetic evaluation.
BACKGROUND: In this paper the authors summarise the primary malignant thyroid tumors (p.m.t.t.) incidence data from their centre over the period 1984-2005. The results are explained in the context of the p.m.t.t. incidence data from the National Cancer Register (1996 2002). METHODS AND RESULTS: Overall, 6434 thyroid operations were indicated and carried out during the sampling period at the authors' institution, of which 365 cases were histologically confirmed p.m.t.t. (5.7% of all histological findings). Specifically, p.m.t.t. were diagnosed in 295 women (80.8%) and 70 men (19.2%), with the most frequent occurrence in the 5th decade and a higher recent incidence in younger age groups. Whereas follicular thyroid carcinomas predominated in the 1984-1989 period (24 cases or 66.7%), the papillary thyroid carcinoma was the most frequent type in 1990-1997 and 1998-2005: 70 (61.4%) and 160 (74.4%) cases respectively. In the context of the national incidence, the authors' institution increasingly contributes to the diagnosis of p.m.t.t. in Slovakia (8.9% in 1996 vs. 13.9% in 2002). However, neither the progress in diagnostic methods nor the capacity expansion for patient examination can explain the increasing incidence of the p.m.t.t. (3.9/10(6) in 1996 vs. 5.6/10(6) in 2002 in women and 1.3/10(6) in 1996 vs. 1.7/10(6) in 2002 in men, respectively). CONCLUSIONS: It remains to be explained why there are significant differences in p.m.t.t. incidence among individual counties. For example, in county Trnava 0.6/10(6) in men in 1996 vs. 1.5/10(6) in 2002; in county Presov 1.2/10(6) in 1996 vs. 2.4/10(6) in 2002. Similarly, in women in county Trnava 3.6/10(6) in 1996 vs. 5.6/10(6) in 2002 and in county Presov 5.4/10(6) in 1996 vs. 8.4/10(6) in 2002. As far as the districts of Slovakia are concerned, data relative to the male population in 2002 indicate zero incidence in 42 out of 79 districts, with the highest incidence (15.9/10(6)) recorded in Svidnik. Likewise, data relative to the female population in 2002 indicate zero incidence in 15 out of 79 districts, with the highest incidence (26.5/10(6)) in Stropkov. These differences call for further (radio)epidemiological, geographical and genetic evaluation.