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Literature DB >> 17371825

Treatment of Staphylococcus aureus biofilm infection by the quorum-sensing inhibitor RIP.

Naomi Balaban¹, Oscar Cirioni, Andrea Giacometti, Roberto Ghiselli, Joel B Braunstein, Carmela Silvestri, Federico Mocchegiani, Vittorio Saba, Giorgio Scalise.

Abstract

The quorum-sensing inhibitor RIP inhibits staphylococcal TRAP/agr systems and both TRAP- and agr-negative strains are deficient in biofilm formation in vivo, indicating the importance of quorum sensing to biofilms in the host. RIP injected systemically into rats has been found to have strong activity in preventing methicillin-resistant Staphylococcus aureus graft infections, suggesting that RIP can be used as a therapeutic agent.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2007 PMID： 17371825 PMCID： PMC1891383 DOI： 10.1128/AAC.01097-06

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

41 in total

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Journal: J Bacteriol Date: 2001-12 Impact factor: 3.490

2. RNAIII inhibiting peptide (RIP) inhibits agr-regulated toxin production.

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Journal: Peptides Date: 2001-10 Impact factor: 3.750

Review 3. Antimicrobial resistance: the example of Staphylococcus aureus.

Authors: Franklin D Lowy
Journal: J Clin Invest Date: 2003-05 Impact factor: 14.808

Review 4. Biofilms as complex differentiated communities.

Authors: P Stoodley; K Sauer; D G Davies; J W Costerton
Journal: Annu Rev Microbiol Date: 2002-01-30 Impact factor: 15.500

5. Prevention of Staphylococcus aureus biofilm on dialysis catheters and adherence to human cells.

Authors: Naomi Balaban; Yael Gov; Arkady Bitler; Johan R Boelaert
Journal: Kidney Int Date: 2003-01 Impact factor: 10.612

6. Regulation of Staphylococcus aureus pathogenesis via target of RNAIII-activating Protein (TRAP).

Authors: N Balaban; T Goldkorn; Y Gov; M Hirshberg; N Koyfman; H R Matthews; R T Nhan; B Singh; O Uziel
Journal: J Biol Chem Date: 2001-01-26 Impact factor: 5.157

7. Prevention of diseases caused by Staphylococcus aureus using the peptide RIP.

Authors: N Balaban; L V Collins; J S Cullor; E B Hume; E Medina-Acosta; O Vieira da Motta; R O'Callaghan; P V Rossitto; M E Shirtliff; L Serafim da Silveira; A Tarkowski; J V Torres
Journal: Peptides Date: 2000-09 Impact factor: 3.750

8. RNAIII inhibiting peptide (RIP), a global inhibitor of Staphylococcus aureus pathogenesis: structure and function analysis.

Authors: Y Gov; A Bitler; G Dell'Acqua; J V Torres; N Balaban
Journal: Peptides Date: 2001-10 Impact factor: 3.750

Review 9. Biofilms: survival mechanisms of clinically relevant microorganisms.

Authors: Rodney M Donlan; J William Costerton
Journal: Clin Microbiol Rev Date: 2002-04 Impact factor: 26.132

10. Use of the quorum-sensing inhibitor RNAIII-inhibiting peptide to prevent biofilm formation in vivo by drug-resistant Staphylococcus epidermidis.

Authors: Naomi Balaban; Andrea Giacometti; Oscar Cirioni; Yael Gov; Roberto Ghiselli; Federico Mocchegiani; Claudio Viticchi; Maria Simona Del Prete; Vittorio Saba; Giorgio Scalise; Giorgio Dell'Acqua
Journal: J Infect Dis Date: 2003-02-07 Impact factor: 5.226

49 in total

Review 1. Small molecule control of bacterial biofilms.

Authors: Roberta J Worthington; Justin J Richards; Christian Melander
Journal: Org Biomol Chem Date: 2012-10-07 Impact factor: 3.876

2. Surface with antimicrobial activity obtained through silane coating with covalently bound polymyxin B.

Authors: M Mohorcič; I Jerman; M Zorko; L Butinar; B Orel; R Jerala; J Friedrich
Journal: J Mater Sci Mater Med Date: 2010-07-28 Impact factor: 3.896

Review 3. Role of quorum sensing in bacterial infections.

Authors: Israel Castillo-Juárez; Toshinari Maeda; Edna Ayerim Mandujano-Tinoco; María Tomás; Berenice Pérez-Eretza; Silvia Julieta García-Contreras; Thomas K Wood; Rodolfo García-Contreras
Journal: World J Clin Cases Date: 2015-07-16 Impact factor: 1.337

Review 4. Novel approaches to the diagnosis, prevention, and treatment of medical device-associated infections.

Authors: Paschalis Vergidis; Robin Patel
Journal: Infect Dis Clin North Am Date: 2012-03 Impact factor: 5.982

5. Mutation of traP in Staphylococcus aureus has no impact on expression of agr or biofilm formation.

Authors: Laura H Tsang; Sonja T Daily; Elizabeth C Weiss; Mark S Smeltzer
Journal: Infect Immun Date: 2007-06-04 Impact factor: 3.441

Review 6. Staphylococcal biofilms.

Authors: M Otto
Journal: Curr Top Microbiol Immunol Date: 2008 Impact factor: 4.291

7. Quorum sensing inhibitory drugs as next generation antimicrobials: worth the effort?

Authors: Thomas Bjarnsholt; Michael Givskov
Journal: Curr Infect Dis Rep Date: 2008-03 Impact factor: 3.725

Review 8. Control of Biofilm Formation: Antibiotics and Beyond.

Authors: Ammar Algburi; Nicole Comito; Dimitri Kashtanov; Leon M T Dicks; Michael L Chikindas
Journal: Appl Environ Microbiol Date: 2017-01-17 Impact factor: 4.792

Review 9. Analysis of bacterial biofilms using NMR-based metabolomics.

Authors: Bo Zhang; Robert Powers
Journal: Future Med Chem Date: 2012-06 Impact factor: 3.808

10. RNAIII-inhibiting peptide affects biofilm formation in a rat model of staphylococcal ureteral stent infection.

Authors: Oscar Cirioni; Roberto Ghiselli; Daniele Minardi; Fiorenza Orlando; Federico Mocchegiani; Carmela Silvestri; Giovanni Muzzonigro; Vittorio Saba; Giorgio Scalise; Naomi Balaban; Andrea Giacometti
Journal: Antimicrob Agents Chemother Date: 2007-09-17 Impact factor: 5.191