OBJECTIVE: To examine the relation between alcohol consumption and risk factors for coronary heart disease in women. DESIGN: Cross sectional study of a stratified random sample of the population grouped into five categories of habitual alcohol consumption. SETTING: People registered with general practitioners at two large health centres in east Bristol, England. SUBJECTS: 1048 women aged 25-69 years. MAIN OUTCOME MEASURES: Fasting plasma concentrations of insulin, total cholesterol, total triglycerides, and high density lipoprotein cholesterol, including its subfractions HDL2 and HDL3, and body mass index. RESULTS: Compared with non-drinkers women consuming a moderate amount of alcohol (1-20 g/day) had lower plasma concentrations of triglycerides, by 0.19 mmol/l (95% confidence interval 0.07 to 0.35); cholesterol, by 0.4 mmol/l (0.19 to 0.61); and insulin, by 1.4 mU/l (0.43 to 1.97) and a lower body mass index, by 1.2 kg/m2 (0.43 to 1.97). They also had higher concentrations of high density lipoprotein cholesterol, by 0.09 mmol/l (0.03 to 0.15); HDL2 cholesterol by 0.05 mmol/l (-0.02 to 0.10) and HDL3 cholesterol, by 0.06 mmol/l (0.06 to 0.11). All these were independent of body mass index, smoking habits, and taking oral contraceptives. CONCLUSIONS: Moderate alcohol consumption is associated with lower levels of cardiovascular risk factors in women. Insulin may have a central role.
OBJECTIVE: To examine the relation between alcohol consumption and risk factors for coronary heart disease in women. DESIGN: Cross sectional study of a stratified random sample of the population grouped into five categories of habitual alcohol consumption. SETTING:People registered with general practitioners at two large health centres in east Bristol, England. SUBJECTS: 1048 women aged 25-69 years. MAIN OUTCOME MEASURES: Fasting plasma concentrations of insulin, total cholesterol, total triglycerides, and high density lipoprotein cholesterol, including its subfractions HDL2 and HDL3, and body mass index. RESULTS: Compared with non-drinkers women consuming a moderate amount of alcohol (1-20 g/day) had lower plasma concentrations of triglycerides, by 0.19 mmol/l (95% confidence interval 0.07 to 0.35); cholesterol, by 0.4 mmol/l (0.19 to 0.61); and insulin, by 1.4 mU/l (0.43 to 1.97) and a lower body mass index, by 1.2 kg/m2 (0.43 to 1.97). They also had higher concentrations of high density lipoprotein cholesterol, by 0.09 mmol/l (0.03 to 0.15); HDL2cholesterol by 0.05 mmol/l (-0.02 to 0.10) and HDL3cholesterol, by 0.06 mmol/l (0.06 to 0.11). All these were independent of body mass index, smoking habits, and taking oral contraceptives. CONCLUSIONS: Moderate alcohol consumption is associated with lower levels of cardiovascular risk factors in women. Insulin may have a central role.
Authors: N E Miller; C H Bolton; T M Hayes; D Bainton; J W Yarnell; I A Baker; P M Sweetnam Journal: J Epidemiol Community Health Date: 1988-09 Impact factor: 3.710
Authors: Ameena T Ahmed; Andrew J Karter; E Margaret Warton; Jennifer U Doan; Constance M Weisner Journal: J Gen Intern Med Date: 2008-01-08 Impact factor: 5.128