BACKGROUND: Migraine is common in the pediatric population. Levetiracetam, an anti-epileptic drug, has shown some efficacy in small prospective adult headache studies. METHODS: We prospectively evaluated levetiracetam in an open-label study in 20 pediatric migraine patients to assess tolerability and efficacy. RESULTS: Eighteen of 20 patients had significant reduction in headache frequency. PedMIDAS showed significant decrease in disability scores, side effects were minimal (mild behavioral changes). CONCLUSION: Levetiracetam had some efficacy in reducing migraine frequency and disability. Further larger studies are warranted, possibly utilizing a placebo-controlled design.
BACKGROUND:Migraine is common in the pediatric population. Levetiracetam, an anti-epileptic drug, has shown some efficacy in small prospective adult headache studies. METHODS: We prospectively evaluated levetiracetam in an open-label study in 20 pediatric migrainepatients to assess tolerability and efficacy. RESULTS: Eighteen of 20 patients had significant reduction in headache frequency. PedMIDAS showed significant decrease in disability scores, side effects were minimal (mild behavioral changes). CONCLUSION:Levetiracetam had some efficacy in reducing migraine frequency and disability. Further larger studies are warranted, possibly utilizing a placebo-controlled design.
Authors: Laura Papetti; Alberto Spalice; Francesco Nicita; Maria Chiara Paolino; Rosa Castaldo; Paola Iannetti; Maria Pia Villa; Pasquale Parisi Journal: J Headache Pain Date: 2010-03-27 Impact factor: 7.277
Authors: Silvia Miano; Pasquale Parisi; Andrea Pelliccia; Anna Luchetti; Maria Chiara Paolino; Maria Pia Villa Journal: Neurol Sci Date: 2008-09-20 Impact factor: 3.307